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  <xs:element id="wgs_LeaseNumberOfRenewalTerms" abstract="false" name="LeaseNumberOfRenewalTerms" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_BuildingHeldUnderCapitalLeaseMember" abstract="true" name="BuildingHeldUnderCapitalLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_PrivateWarrantMember" abstract="true" name="PrivateWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAndAccruedExpenses" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAndAccruedExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LineOfCreditCovenantAdjustedQuickRatio" abstract="false" name="LineOfCreditCovenantAdjustedQuickRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationFirstMilestonePaymentPercentageOfAggregate" abstract="false" name="BusinessCombinationContingentConsiderationFirstMilestonePaymentPercentageOfAggregate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_ChangeInFairMarketValueOfWarrantAndEarnOutContingentLiabilities" abstract="false" name="ChangeInFairMarketValueOfWarrantAndEarnOutContingentLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsReMeasurementPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsReMeasurementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wgs_SaleOfStockPeriodToPurchaseAdditionalShares" abstract="false" name="SaleOfStockPeriodToPurchaseAdditionalShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wgs_RelatedPartyTSAAgreementMember" abstract="true" name="RelatedPartyTSAAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_OperatingLossCarryforwardsSubjectToExpiration" abstract="false" name="OperatingLossCarryforwardsSubjectToExpiration" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_FurnitureFixturesAndOtherEquipmentMember" abstract="true" name="FurnitureFixturesAndOtherEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LesseeFinanceLeaseInterestRate" abstract="false" name="LesseeFinanceLeaseInterestRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_ProceedsFromIssuanceOfCommonStockNetOfDiscountsAndCommissions" abstract="false" name="ProceedsFromIssuanceOfCommonStockNetOfDiscountsAndCommissions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_CommonStockThresholdTradingDays" abstract="false" name="CommonStockThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_ClassOfWarrantOrRightTargetSharePriceOfWarrantsOrRightsForRedemption" abstract="false" name="ClassOfWarrantOrRightTargetSharePriceOfWarrantsOrRightsForRedemption" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityUndiscountedExcessAmount" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityUndiscountedExcessAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_PublicOfferingSharesUnderwriterOptionsGrantedSharesPurchased" abstract="false" name="PublicOfferingSharesUnderwriterOptionsGrantedSharesPurchased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_RevenueRecognitionStandardPaymentTerm" abstract="false" name="RevenueRecognitionStandardPaymentTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wgs_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsTransactionCosts" abstract="false" name="DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsTransactionCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_EmployeeStockOptionAndRestrictedStockUnitsMember" abstract="true" name="EmployeeStockOptionAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_EarnOutLiabilityMember" abstract="true" name="EarnOutLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_SaleOfStockPublicOfferingSharesAuthorized" abstract="false" name="SaleOfStockPublicOfferingSharesAuthorized" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_EarnOutSharesMember" abstract="true" name="EarnOutSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_ClassACommonStockEqualsOrExceedsThresholdOneMember" abstract="true" name="ClassACommonStockEqualsOrExceedsThresholdOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationPercentageOfMilestonePaymentBasedOnRevenueTarget" abstract="false" name="BusinessCombinationContingentConsiderationPercentageOfMilestonePaymentBasedOnRevenueTarget" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_ContingentConsiderationMilestoneTwoMember" abstract="true" name="ContingentConsiderationMilestoneTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_GovernmentAssistanceCARESActEmployeeRetentionCreditMember" abstract="true" name="GovernmentAssistanceCARESActEmployeeRetentionCreditMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_TemporaryEquityCapitalContributionValue" abstract="false" name="TemporaryEquityCapitalContributionValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LossContingencySettlementAgreementPeriod" abstract="false" name="LossContingencySettlementAgreementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wgs_January2023PublicOfferingMember" abstract="true" name="January2023PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_DECDLoanAgreementMember" abstract="true" name="DECDLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LitigationSettlementPeriodicAmountAwardedToOtherParty" abstract="false" name="LitigationSettlementPeriodicAmountAwardedToOtherParty" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LeaseLiabilitiesNoncurrent" abstract="false" name="LeaseLiabilitiesNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_WarrantLiability" abstract="false" name="WarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_NoncashLeaseExpense" abstract="false" name="NoncashLeaseExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_TradeNamesTrademarksAndDevelopedTechnologyMember" abstract="true" name="TradeNamesTrademarksAndDevelopedTechnologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LeaseLiabilities" abstract="false" name="LeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LineOfCreditFacilityCovenantLiquidityThreshold" abstract="false" name="LineOfCreditFacilityCovenantLiquidityThreshold" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_EquipmentSupplierMember" abstract="true" name="EquipmentSupplierMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesShareHigh" abstract="false" name="BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesShareHigh" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_LeaseLiabilitiesCurrent" abstract="false" name="LeaseLiabilitiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_DebtInstrumentPercentageOfExistingIssuedAndOutstandingShares" abstract="false" name="DebtInstrumentPercentageOfExistingIssuedAndOutstandingShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityPaymentsDue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_AccruedSeveranceCurrent" abstract="false" name="AccruedSeveranceCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_SoftwareDevelopmentCostsIncurredButNotYetPaid" abstract="false" name="SoftwareDevelopmentCostsIncurredButNotYetPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LineOfCreditCovenantTrailingPeriodForMinimumRevenueTargets" abstract="false" name="LineOfCreditCovenantTrailingPeriodForMinimumRevenueTargets" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wgs_DebtInstrumentFundingCommitment" abstract="false" name="DebtInstrumentFundingCommitment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_CommonStockThresholdConsecutiveTradingDays" abstract="false" name="CommonStockThresholdConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_EarnOutRestrictedStockUnitsMember" abstract="true" name="EarnOutRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_DiagnosticTestMember" abstract="true" name="DiagnosticTestMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_NumberOfDaysForWrittenNoticeOfRedemption" abstract="false" name="NumberOfDaysForWrittenNoticeOfRedemption" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_DebtInstrumentConditionalPrincipalForgivenessMaximum" abstract="false" name="DebtInstrumentConditionalPrincipalForgivenessMaximum" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_CommonStockVotingRightsVotesEntitledForEachShare" abstract="false" name="CommonStockVotingRightsVotesEntitledForEachShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_January2023AdditionalPurchaseOfferingMember" abstract="true" name="January2023AdditionalPurchaseOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_IncreaseDecreaseInDueToFromRelatedParties" abstract="false" name="IncreaseDecreaseInDueToFromRelatedParties" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_RelatedPartyExpensesMember" abstract="true" name="RelatedPartyExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wgs_GeneDXHolding2IncMember" abstract="true" name="GeneDXHolding2IncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_MinimumThresholdPriceOfCommonStockSpecifiedToSendNoticeOfRedemptionToTheWarrantHolders" abstract="false" name="MinimumThresholdPriceOfCommonStockSpecifiedToSendNoticeOfRedemptionToTheWarrantHolders" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="wgs_EffectiveIncomeTaxRateReconciliationNondeductibleExpensePayForCoveredEmployeesLimitationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpensePayForCoveredEmployeesLimitationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="wgs_DECDLoanAgreementFinalPhaseFundingMember" abstract="true" name="DECDLoanAgreementFinalPhaseFundingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_OperatingFinanceLeaseLiabilityAbstract" abstract="true" name="OperatingFinanceLeaseLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wgs_PayorAMember" abstract="true" name="PayorAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_DebtInstrumentNumberOfMilestones" abstract="false" name="DebtInstrumentNumberOfMilestones" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_BusinessAcquisitionReceivablesRelatedToAcquisitionClosingWorkingCapitalAdjustment" abstract="false" name="BusinessAcquisitionReceivablesRelatedToAcquisitionClosingWorkingCapitalAdjustment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" abstract="true" name="CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wgs_ResearchAndExperimentalTaxCreditCarryforwardMember" abstract="true" name="ResearchAndExperimentalTaxCreditCarryforwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_SoftwareProviderMember" abstract="true" name="SoftwareProviderMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LesseeOperatingLeaseEarlyTerminationPeriod" abstract="false" name="LesseeOperatingLeaseEarlyTerminationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wgs_LineOfCreditFacilityCovenantOutstandingBorrowings" abstract="false" name="LineOfCreditFacilityCovenantOutstandingBorrowings" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_RedemptionPricePerWarrant" abstract="false" name="RedemptionPricePerWarrant" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="wgs_DeferredTaxAssetsTaxDeferredExpenseEmployerTaxes" abstract="false" name="DeferredTaxAssetsTaxDeferredExpenseEmployerTaxes" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNumberOfSharesAvailableForGrantOutstanding" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNumberOfSharesAvailableForGrantOutstanding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_DiagnosticTestThirdPartyInsuranceMember" abstract="true" name="DiagnosticTestThirdPartyInsuranceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_DeferredTaxAssetsResearchAndDevelopmentAmortization" abstract="false" name="DeferredTaxAssetsResearchAndDevelopmentAmortization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_GovernmentAssistanceDomain" abstract="true" name="GovernmentAssistanceDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_PayorDMember" abstract="true" name="PayorDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_EmergingGrowthCompanyPolicyTextBlock" abstract="false" name="EmergingGrowthCompanyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="wgs_OperatingLossCarryforwardsNotSubjectToExpiration" abstract="false" name="OperatingLossCarryforwardsNotSubjectToExpiration" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_DECDLoanAgreementPhase3FundingMember" abstract="true" name="DECDLoanAgreementPhase3FundingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LesseeOperatingLeaseLandToTotalValuePercentage" abstract="false" name="LesseeOperatingLeaseLandToTotalValuePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_ClassACommonStockEqualsOrExceedsThresholdTwoMember" abstract="true" name="ClassACommonStockEqualsOrExceedsThresholdTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_CommonStockThresholdNumberOfTradingDaysBeforeNoticeOfRedemption" abstract="false" name="CommonStockThresholdNumberOfTradingDaysBeforeNoticeOfRedemption" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_StockIssuedDuringPeriodConversionOfTemporaryEquityAsPartOfReorganizationShares" abstract="false" name="StockIssuedDuringPeriodConversionOfTemporaryEquityAsPartOfReorganizationShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_EffectiveIncomeTaxRateReconciliationUnrealizedFairMarketValueGainOnWarrants" abstract="false" name="EffectiveIncomeTaxRateReconciliationUnrealizedFairMarketValueGainOnWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_PublicOfferingSharesSubjectToShareholderApproval" abstract="false" name="PublicOfferingSharesSubjectToShareholderApproval" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_ShareBasedPaymentArrangementNumberOfIndividualsGranted" abstract="false" name="ShareBasedPaymentArrangementNumberOfIndividualsGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wgs_PublicWarrantMember" abstract="true" name="PublicWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_A2021EmployeeStockPurchasePlanMember" abstract="true" name="A2021EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_PaymentForSettlementOfUnvestedStockAppreciationRights" abstract="false" name="PaymentForSettlementOfUnvestedStockAppreciationRights" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableAfterTermOfOptionsNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableAfterTermOfOptionsNumber" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_FinanceLeaseCosts" abstract="false" name="FinanceLeaseCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_OrganizationAndDescriptionOfBusinessLineItems" abstract="true" name="OrganizationAndDescriptionOfBusinessLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wgs_DiagnosticTestInstitutionalCustomersMember" abstract="true" name="DiagnosticTestInstitutionalCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_TwoRenewalPeriodsMember" abstract="true" name="TwoRenewalPeriodsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_RelatedPartyServiceAgreementsMember" abstract="true" name="RelatedPartyServiceAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_TemporaryEquityCapitalContribution" abstract="false" name="TemporaryEquityCapitalContribution" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_GovernmentAssistanceCARESActProviderReliefFundMember" abstract="true" name="GovernmentAssistanceCARESActProviderReliefFundMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_BusinessAcquisitionShareConversionRatio" abstract="false" name="BusinessAcquisitionShareConversionRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationMilestonePaymentPercentage" abstract="false" name="BusinessCombinationContingentConsiderationMilestonePaymentPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_RedemptionOnWarrantHolders" abstract="false" name="RedemptionOnWarrantHolders" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="wgs_CMLSHoldingsLLCMember" abstract="true" name="CMLSHoldingsLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_ShareBasedCompensationModificationReclassification" abstract="false" name="ShareBasedCompensationModificationReclassification" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationRevenueTargetOfMilestoneEvent" abstract="false" name="BusinessCombinationContingentConsiderationRevenueTargetOfMilestoneEvent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_SupplierAMember" abstract="true" name="SupplierAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_ContingentMilestoneLiabilityMember" abstract="true" name="ContingentMilestoneLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_RelatedPartyTransactionFundingCommitmentToBeReceivedMaximum" abstract="false" name="RelatedPartyTransactionFundingCommitmentToBeReceivedMaximum" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_AccruedPurchases" abstract="false" name="AccruedPurchases" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LegacySema4Member" abstract="true" name="LegacySema4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_PayorEMember" abstract="true" name="PayorEMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationSecondMilestonePaymentEstimatedRevenue" abstract="false" name="BusinessCombinationContingentConsiderationSecondMilestonePaymentEstimatedRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationFirstMilestonePayment" abstract="false" name="BusinessCombinationContingentConsiderationFirstMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_ProceedsFromGovernmentAssistance" abstract="false" name="ProceedsFromGovernmentAssistance" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_PublicWarrantsMember" abstract="true" name="PublicWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationFirstMilestonePaymentEstimatedRevenue" abstract="false" name="BusinessCombinationContingentConsiderationFirstMilestonePaymentEstimatedRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_ContingentConsiderationMilestoneOneMember" abstract="true" name="ContingentConsiderationMilestoneOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiability" abstract="false" name="LesseeOperatingAndFinanceAndLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_PublicOfferingSharesUnderwriterOptionsExercisedSharesPurchased" abstract="false" name="PublicOfferingSharesUnderwriterOptionsExercisedSharesPurchased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationSecondMilestonePayment" abstract="false" name="BusinessCombinationContingentConsiderationSecondMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths" abstract="false" name="LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_GeneDxMember" abstract="true" name="GeneDxMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_A2017StockIncentivePlanMember" abstract="true" name="A2017StockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_OrganizationAndDescriptionOfBusinessTable" abstract="true" name="OrganizationAndDescriptionOfBusinessTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="wgs_StockIssuedDuringPeriodConversionOfTemporaryEquityAsPartOfReorganization" abstract="false" name="StockIssuedDuringPeriodConversionOfTemporaryEquityAsPartOfReorganization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_DiagnosticTestSelfPayMember" abstract="true" name="DiagnosticTestSelfPayMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_IndemnificationLiabilitiesCurrent" abstract="false" name="IndemnificationLiabilitiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_WeightedAverageDiscountRateAbstract" abstract="true" name="WeightedAverageDiscountRateAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wgs_BusinessCombinationContingentConsiderationSecondMilestonePaymentPercentageOfAggregate" abstract="false" name="BusinessCombinationContingentConsiderationSecondMilestonePaymentPercentageOfAggregate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wgs_BusinessAcquisitionInitialPublicOffering" abstract="false" name="BusinessAcquisitionInitialPublicOffering" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_ReverseRecapitalizationExchangeRatio" abstract="false" name="ReverseRecapitalizationExchangeRatio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="wgs_BusinessAcquisitionCashAndConsiderationHeldAsEscrowPeriod" abstract="false" name="BusinessAcquisitionCashAndConsiderationHeldAsEscrowPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wgs_ConversionRatio" abstract="false" name="ConversionRatio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="wgs_SVBAgreementMember" abstract="true" name="SVBAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_PayorBMember" abstract="true" name="PayorBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_DebtInstrumentCovenantEligibleDebtForgiveness" abstract="false" name="DebtInstrumentCovenantEligibleDebtForgiveness" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_NumberOfSharesIssuedAndOutstanding" abstract="false" name="NumberOfSharesIssuedAndOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_SupplierBMember" abstract="true" name="SupplierBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_PaymentOfDeferredPayrollTaxes" abstract="false" name="PaymentOfDeferredPayrollTaxes" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_Sema4OpCoIncMember" abstract="true" name="Sema4OpCoIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_A2021PlanMember" abstract="true" name="A2021PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_OPKOMember" abstract="true" name="OPKOMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
