<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019f14ce-b7fd-7b5f-8cfa-d5f38b9ccc1d,g:b830884a-b976-4d37-8af1-61878cbedccd-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.genedx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="wgs-20260630.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f14ce-b964-7b53-acbc-8194e1e8d27e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019f14ce-b964-773d-b010-be0b5aebe966" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f14ce-b964-7b53-acbc-8194e1e8d27e" xlink:to="loc_us-gaap_Liabilities_019f14ce-b964-773d-b010-be0b5aebe966" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019f14ce-b964-77ca-b57a-84b51fe1910b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f14ce-b964-7b53-acbc-8194e1e8d27e" xlink:to="loc_us-gaap_StockholdersEquity_019f14ce-b964-77ca-b57a-84b51fe1910b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019f14ce-b964-7186-8643-3395659472ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f14ce-b964-7b53-acbc-8194e1e8d27e" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019f14ce-b964-7186-8643-3395659472ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019f14ce-b964-7848-ac83-8d2d7cca29b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019f14ce-b964-710a-aa91-b95f711bf482" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f14ce-b964-7848-ac83-8d2d7cca29b5" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019f14ce-b964-710a-aa91-b95f711bf482" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019f14ce-b964-72cf-a379-87dae8b1b0ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f14ce-b964-7848-ac83-8d2d7cca29b5" xlink:to="loc_us-gaap_LiabilitiesCurrent_019f14ce-b964-72cf-a379-87dae8b1b0ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019f14ce-b964-7452-ad51-67b2e2c00945" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f14ce-b964-7848-ac83-8d2d7cca29b5" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019f14ce-b964-7452-ad51-67b2e2c00945" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019f14ce-b964-7870-a8f1-df017ac02538" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f14ce-b964-7848-ac83-8d2d7cca29b5" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019f14ce-b964-7870-a8f1-df017ac02538" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseLiabilitiesNoncurrent_019f14ce-b964-7d4e-b011-3bc70ffb595a" xlink:href="wgs-20260630.xsd#wgs_LeaseLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f14ce-b964-7848-ac83-8d2d7cca29b5" xlink:to="loc_wgs_LeaseLiabilitiesNoncurrent_019f14ce-b964-7d4e-b011-3bc70ffb595a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019f14ce-b964-7723-b1ee-6112cf36a6fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019f14ce-b964-719a-8cd8-4b7ae3d4475f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f14ce-b964-7723-b1ee-6112cf36a6fb" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019f14ce-b964-719a-8cd8-4b7ae3d4475f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f14ce-b964-7ade-8c87-4062174af493" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f14ce-b964-7723-b1ee-6112cf36a6fb" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f14ce-b964-7ade-8c87-4062174af493" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019f14ce-b964-7084-80b3-24a32234f064" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f14ce-b964-7723-b1ee-6112cf36a6fb" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019f14ce-b964-7084-80b3-24a32234f064" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_019f14ce-b964-730b-83cf-812dcc5c7c4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f14ce-b964-7723-b1ee-6112cf36a6fb" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_019f14ce-b964-730b-83cf-812dcc5c7c4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019f14ce-b964-7c7c-b739-c13b1809af1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f14ce-b964-7723-b1ee-6112cf36a6fb" xlink:to="loc_us-gaap_InventoryNet_019f14ce-b964-7c7c-b739-c13b1809af1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019f14ce-b964-7941-9a53-dcc8b274a8e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019f14ce-b964-7b70-bef4-a8d3711d1abf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f14ce-b964-7941-9a53-dcc8b274a8e8" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019f14ce-b964-7b70-bef4-a8d3711d1abf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseLiabilitiesCurrent_019f14ce-b964-7bd2-bd4f-440d4229810c" xlink:href="wgs-20260630.xsd#wgs_LeaseLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f14ce-b964-7941-9a53-dcc8b274a8e8" xlink:to="loc_wgs_LeaseLiabilitiesCurrent_019f14ce-b964-7bd2-bd4f-440d4229810c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019f14ce-b964-7c8e-981c-3cf01f2af0f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f14ce-b964-7941-9a53-dcc8b274a8e8" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019f14ce-b964-7c8e-981c-3cf01f2af0f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019f14ce-b964-7783-8b0a-0c1c88014c65" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019f14ce-b964-7388-b087-1fe09a44b749" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f14ce-b964-7783-8b0a-0c1c88014c65" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019f14ce-b964-7388-b087-1fe09a44b749" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019f14ce-b964-737e-b3ca-4e4011119fc1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f14ce-b964-7783-8b0a-0c1c88014c65" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019f14ce-b964-737e-b3ca-4e4011119fc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019f14ce-b964-7ed1-af65-da8fb2241c31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f14ce-b964-7783-8b0a-0c1c88014c65" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019f14ce-b964-7ed1-af65-da8fb2241c31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019f14ce-b964-7f56-bd55-40ea6d31d1af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f14ce-b964-7783-8b0a-0c1c88014c65" xlink:to="loc_us-gaap_PreferredStockValue_019f14ce-b964-7f56-bd55-40ea6d31d1af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019f14ce-b964-73f4-be93-9f54424a39e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f14ce-b964-7783-8b0a-0c1c88014c65" xlink:to="loc_us-gaap_CommonStockValue_019f14ce-b964-73f4-be93-9f54424a39e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019f14ce-b964-760a-a01a-c099f7249430" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019f14ce-b964-7bcd-a3b4-123bcc94f2d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f14ce-b964-760a-a01a-c099f7249430" xlink:to="loc_us-gaap_AssetsCurrent_019f14ce-b964-7bcd-a3b4-123bcc94f2d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019f14ce-b964-7a96-a0e3-917e459cee89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f14ce-b964-760a-a01a-c099f7249430" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019f14ce-b964-7a96-a0e3-917e459cee89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019f14ce-b964-7816-b0c2-153410dbb7ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f14ce-b964-760a-a01a-c099f7249430" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019f14ce-b964-7816-b0c2-153410dbb7ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019f14ce-b964-747a-b948-04ea6ed03e35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f14ce-b964-760a-a01a-c099f7249430" xlink:to="loc_us-gaap_Goodwill_019f14ce-b964-747a-b948-04ea6ed03e35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019f14ce-b964-7868-b720-49794a8e94b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f14ce-b964-760a-a01a-c099f7249430" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019f14ce-b964-7868-b720-49794a8e94b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019f14ce-b964-75fa-b8de-0374ecbda57f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f14ce-b964-760a-a01a-c099f7249430" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019f14ce-b964-75fa-b8de-0374ecbda57f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossIncomeUnaudited" xlink:type="simple" xlink:href="wgs-20260630.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLossIncomeUnaudited"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossIncomeUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f14ce-b964-700a-bbd8-5e65e81ec995" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019f14ce-b964-7cb4-afdf-f16988bd422a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f14ce-b964-700a-bbd8-5e65e81ec995" xlink:to="loc_us-gaap_OperatingIncomeLoss_019f14ce-b964-7cb4-afdf-f16988bd422a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019f14ce-b964-77c8-b6dd-b0c11279c19c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f14ce-b964-700a-bbd8-5e65e81ec995" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019f14ce-b964-77c8-b6dd-b0c11279c19c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f14ce-b964-7f91-afe2-386bee0b2503" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019f14ce-b964-732b-a03f-2a93b0122b15" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019f14ce-b964-7f91-afe2-386bee0b2503" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019f14ce-b964-732b-a03f-2a93b0122b15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f14ce-b964-7168-bc5d-1632d9fd8581" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019f14ce-b964-7f91-afe2-386bee0b2503" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f14ce-b964-7168-bc5d-1632d9fd8581" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019f14ce-b964-78bc-9009-dd00b0f30235" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities_019f14ce-b964-7d60-80db-1d231ea7b38e" xlink:href="wgs-20260630.xsd#wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f14ce-b964-78bc-9009-dd00b0f30235" xlink:to="loc_wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities_019f14ce-b964-7d60-80db-1d231ea7b38e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019f14ce-b964-721d-b7b9-688541e966fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f14ce-b964-78bc-9009-dd00b0f30235" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019f14ce-b964-721d-b7b9-688541e966fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019f14ce-b964-720f-a8f0-8b8379ebf993" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f14ce-b964-78bc-9009-dd00b0f30235" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019f14ce-b964-720f-a8f0-8b8379ebf993" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019f14ce-b964-792e-8865-e1fabe0af6f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019f14ce-b964-78bc-9009-dd00b0f30235" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019f14ce-b964-792e-8865-e1fabe0af6f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019f14ce-b964-7d08-9bdc-60de33a96a48" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019f14ce-b964-77d5-932a-6f4733651cff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019f14ce-b964-7d08-9bdc-60de33a96a48" xlink:to="loc_us-gaap_GrossProfit_019f14ce-b964-77d5-932a-6f4733651cff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019f14ce-b964-7623-b1b1-f849b3d9a9ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019f14ce-b964-7d08-9bdc-60de33a96a48" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019f14ce-b964-7623-b1b1-f849b3d9a9ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019f14ce-b964-7b98-bd84-ee03d7094e54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019f14ce-b964-7d08-9bdc-60de33a96a48" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019f14ce-b964-7b98-bd84-ee03d7094e54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019f14ce-b964-7672-b292-2ada89f30c91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019f14ce-b964-7d08-9bdc-60de33a96a48" xlink:to="loc_us-gaap_AssetImpairmentCharges_019f14ce-b964-7672-b292-2ada89f30c91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019f14ce-b964-77c2-a2e3-78155905b112" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019f14ce-b964-73ba-b4e2-c9b6db052815" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019f14ce-b964-77c2-a2e3-78155905b112" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019f14ce-b964-73ba-b4e2-c9b6db052815" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019f14ce-b964-7842-b40a-85464350f2a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019f14ce-b964-77c2-a2e3-78155905b112" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019f14ce-b964-7842-b40a-85464350f2a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f14ce-b964-7d1d-a603-3f887e1798dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019f14ce-b964-7c78-85df-1533597dbc21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f14ce-b964-7d1d-a603-3f887e1798dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019f14ce-b964-7c78-85df-1533597dbc21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f14ce-b964-7373-928b-d522e7d0e791" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f14ce-b964-7d1d-a603-3f887e1798dc" xlink:to="loc_us-gaap_NetIncomeLoss_019f14ce-b964-7373-928b-d522e7d0e791" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="wgs-20260630.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f14ce-b964-7312-af11-724654fee708" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f14ce-b964-73dc-81d0-ab70094832e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f14ce-b964-7312-af11-724654fee708" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f14ce-b964-73dc-81d0-ab70094832e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f14ce-b964-7db9-b7d3-4875345e8e6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f14ce-b964-7312-af11-724654fee708" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f14ce-b964-7db9-b7d3-4875345e8e6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f14ce-b964-7718-baf6-2dce7500817c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f14ce-b964-7312-af11-724654fee708" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f14ce-b964-7718-baf6-2dce7500817c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f221c-af39-7087-b2f1-c59d58d97c77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019f221c-af39-7c73-b14c-6a081a9fa516" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f221c-af39-7087-b2f1-c59d58d97c77" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019f221c-af39-7c73-b14c-6a081a9fa516" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019f221c-af39-7a58-a806-926161b6bc02" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f221c-af39-7087-b2f1-c59d58d97c77" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019f221c-af39-7a58-a806-926161b6bc02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019f221c-af39-71dd-91e4-c58b8bdb7759" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f221c-af39-7087-b2f1-c59d58d97c77" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019f221c-af39-71dd-91e4-c58b8bdb7759" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019f221c-af39-7a72-8a4f-c3e12a65719d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f221c-af39-7087-b2f1-c59d58d97c77" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019f221c-af39-7a72-8a4f-c3e12a65719d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f221c-af39-7ec1-94b0-a0ee1134ac7a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f221c-af39-7087-b2f1-c59d58d97c77" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f221c-af39-7ec1-94b0-a0ee1134ac7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019f2219-a35a-727a-9480-bc74e4b94385" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019f2219-a35a-727a-9480-bc74e4b94385" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_019f2219-a35a-725a-9b18-33dc58f7beee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_019f2219-a35a-725a-9b18-33dc58f7beee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019f2219-a35a-7779-9dae-d875e0ff102a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019f2219-a35a-7779-9dae-d875e0ff102a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_019f2219-a35a-7095-93f3-eef63afc002f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_019f2219-a35a-7095-93f3-eef63afc002f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019f2219-a35b-7ef2-b155-ccd129477bac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019f2219-a35b-7ef2-b155-ccd129477bac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019f2219-a35b-7cac-a184-dd0c86c4a4d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019f2219-a35b-7cac-a184-dd0c86c4a4d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_019f3ac7-30e1-7f2c-a23b-6710c4811f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f2219-a35a-707e-adde-a6b9cb3f1c76" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_019f3ac7-30e1-7f2c-a23b-6710c4811f6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_019f2227-41b3-76b1-88f9-8a876ffb40d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_019f2227-41b3-76b1-88f9-8a876ffb40d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019f2227-41b3-7528-a9f2-a501013b9cbc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_ShareBasedCompensation_019f2227-41b3-7528-a9f2-a501013b9cbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019f2227-41b3-7dc4-a3d1-dc8c327f74ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019f2227-41b3-7dc4-a3d1-dc8c327f74ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019f2227-41b3-7e02-8d2f-46cf9959f876" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019f2227-41b3-7e02-8d2f-46cf9959f876" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_019f2227-41b3-702b-a007-6130c96e5ede" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_019f2227-41b3-702b-a007-6130c96e5ede" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019f2227-41b3-78f8-8d77-fdaa08cb309c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019f2227-41b3-78f8-8d77-fdaa08cb309c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019f2227-41b3-7e14-a3af-42ee0984e60d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_AssetImpairmentCharges_019f2227-41b3-7e14-a3af-42ee0984e60d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f2227-41b3-7654-9760-7b4c9039984f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_NetIncomeLoss_019f2227-41b3-7654-9760-7b4c9039984f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ChangeInThirdPartyPayorReserves_019f2227-41b3-799d-a0d8-3982e7813c45" xlink:href="wgs-20260630.xsd#wgs_ChangeInThirdPartyPayorReserves"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_wgs_ChangeInThirdPartyPayorReserves_019f2227-41b3-799d-a0d8-3982e7813c45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019f2227-41b3-77a4-93ed-d5c6035cb095" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019f2227-41b3-77a4-93ed-d5c6035cb095" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019f2227-41b3-71ef-96d6-e4be005ab0ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019f2227-41b3-71ef-96d6-e4be005ab0ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019f2227-41b3-7e61-8d74-ff9e5eb72e31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019f2227-41b3-7e61-8d74-ff9e5eb72e31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019f2227-41b3-7e9c-9f14-7d45f7796504" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f2227-41b3-7b02-a08e-26e5d7c8f541" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019f2227-41b3-7e9c-9f14-7d45f7796504" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_019f14ce-b965-79d1-9bb5-357dc538c2db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_019f14ce-b965-775e-8563-1014c2bf1a27" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_019f14ce-b965-79d1-9bb5-357dc538c2db" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_019f14ce-b965-775e-8563-1014c2bf1a27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_019f14ce-b965-7c4e-9ea6-980f3c8a7fe9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_019f14ce-b965-79d1-9bb5-357dc538c2db" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_019f14ce-b965-7c4e-9ea6-980f3c8a7fe9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019f14ce-b965-747b-930f-3a6148b096f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_CashEquivalentsAndMarketableSecuritiesFairValueDisclosure_019f14ce-b965-71d6-b7e4-cd147893671d" xlink:href="wgs-20260630.xsd#wgs_CashEquivalentsAndMarketableSecuritiesFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019f14ce-b965-747b-930f-3a6148b096f5" xlink:to="loc_wgs_CashEquivalentsAndMarketableSecuritiesFairValueDisclosure_019f14ce-b965-71d6-b7e4-cd147893671d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#PropertyandEquipmentnetScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019f14ce-ba21-7a65-abad-08d33e007c3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019f14ce-ba21-71e3-8e2d-2fb1339d82b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019f14ce-ba21-7a65-abad-08d33e007c3e" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019f14ce-ba21-71e3-8e2d-2fb1339d82b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019f14ce-ba21-774c-9456-21414733c3be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019f14ce-ba21-7a65-abad-08d33e007c3e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019f14ce-ba21-774c-9456-21414733c3be" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/GoodwillandIntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#GoodwillandIntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/GoodwillandIntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019f14ce-ba22-781b-8e05-253e3ddb747b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019f14ce-ba22-7b89-8ea1-669543495c59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019f14ce-ba22-781b-8e05-253e3ddb747b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019f14ce-ba22-7b89-8ea1-669543495c59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019f14ce-ba22-7e48-b1a9-9778b939b712" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019f14ce-ba22-781b-8e05-253e3ddb747b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019f14ce-ba22-7e48-b1a9-9778b939b712" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_FiniteLivedIntangibleAssetsAccumulatedImpairment_019f14ce-ba22-7f8f-82c5-3ea79db53c18" xlink:href="wgs-20260630.xsd#wgs_FiniteLivedIntangibleAssetsAccumulatedImpairment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019f14ce-ba22-781b-8e05-253e3ddb747b" xlink:to="loc_wgs_FiniteLivedIntangibleAssetsAccumulatedImpairment_019f14ce-ba22-7f8f-82c5-3ea79db53c18" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/LongTermDebtScheduleofLongTermDebtMaturitiesDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#LongTermDebtScheduleofLongTermDebtMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/LongTermDebtScheduleofLongTermDebtMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019f14ce-ba22-7815-8cec-0e7e67714bdb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019f14ce-ba22-7951-b42d-0fd59efd69a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019f14ce-ba22-7815-8cec-0e7e67714bdb" xlink:to="loc_us-gaap_LongTermDebt_019f14ce-ba22-7951-b42d-0fd59efd69a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_019f14ce-ba22-7d0c-aba0-d9c51651874e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNoncurrentNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019f14ce-ba22-7815-8cec-0e7e67714bdb" xlink:to="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_019f14ce-ba22-7d0c-aba0-d9c51651874e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligation_019f14ce-ba22-71cd-901e-1f48e33fc843" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PurchaseObligation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationFutureMinimumPaymentsRemainderOfFiscalYear_019f14ce-ba22-7647-b7b4-65f37db8630f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PurchaseObligationFutureMinimumPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_019f14ce-ba22-71cd-901e-1f48e33fc843" xlink:to="loc_us-gaap_PurchaseObligationFutureMinimumPaymentsRemainderOfFiscalYear_019f14ce-ba22-7647-b7b4-65f37db8630f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_019f14ce-ba22-775c-b927-8ae3d78a6b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PurchaseObligationDueInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_019f14ce-ba22-71cd-901e-1f48e33fc843" xlink:to="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_019f14ce-ba22-775c-b927-8ae3d78a6b2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInSecondYear_019f14ce-ba22-76bc-a971-3241581069fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PurchaseObligationDueInSecondYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_019f14ce-ba22-71cd-901e-1f48e33fc843" xlink:to="loc_us-gaap_PurchaseObligationDueInSecondYear_019f14ce-ba22-76bc-a971-3241581069fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInThirdYear_019f14ce-ba22-7199-aeb3-3ce5623ddc5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PurchaseObligationDueInThirdYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_019f14ce-ba22-71cd-901e-1f48e33fc843" xlink:to="loc_us-gaap_PurchaseObligationDueInThirdYear_019f14ce-ba22-7199-aeb3-3ce5623ddc5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInFourthYear_019f14ce-ba22-7747-b678-16fde50d5be3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PurchaseObligationDueInFourthYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_019f14ce-ba22-71cd-901e-1f48e33fc843" xlink:to="loc_us-gaap_PurchaseObligationDueInFourthYear_019f14ce-ba22-7747-b678-16fde50d5be3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#SupplementalFinancialInformationScheduleofCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f14ce-ba22-767f-b143-6ccc94a3972a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f14ce-ba22-7754-ae1b-de00b7b7c54c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f14ce-ba22-767f-b143-6ccc94a3972a" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f14ce-ba22-7754-ae1b-de00b7b7c54c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_019f14ce-ba22-7958-9dcb-985d99057fa1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f14ce-ba22-767f-b143-6ccc94a3972a" xlink:to="loc_us-gaap_RestrictedCash_019f14ce-ba22-7958-9dcb-985d99057fa1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#SupplementalFinancialInformationScheduleofPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019f14ce-ba22-724b-8fee-84863efc8605" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_019f14ce-ba22-78c9-976e-903061f396b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019f14ce-ba22-724b-8fee-84863efc8605" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_019f14ce-ba22-78c9-976e-903061f396b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019f14ce-ba22-78ff-ac17-cbc3e936388c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019f14ce-ba22-724b-8fee-84863efc8605" xlink:to="loc_us-gaap_OtherAssetsCurrent_019f14ce-ba22-78ff-ac17-cbc3e936388c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofAccountsPayableandAccruedExpensesDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#SupplementalFinancialInformationScheduleofAccountsPayableandAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofAccountsPayableandAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019f14ce-ba22-73f6-b1cc-fc83ec7acfa2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019f14ce-ba22-72fe-ba7a-3b5606dde2a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019f14ce-ba22-73f6-b1cc-fc83ec7acfa2" xlink:to="loc_us-gaap_AccountsPayableCurrent_019f14ce-ba22-72fe-ba7a-3b5606dde2a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019f14ce-ba22-7cb2-a3af-3417f0438bf4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019f14ce-ba22-73f6-b1cc-fc83ec7acfa2" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019f14ce-ba22-7cb2-a3af-3417f0438bf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ThirdPartyPayorReserveCurrent_019f14ce-ba22-78d7-a115-99da0afe555c" xlink:href="wgs-20260630.xsd#wgs_ThirdPartyPayorReserveCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019f14ce-ba22-73f6-b1cc-fc83ec7acfa2" xlink:to="loc_wgs_ThirdPartyPayorReserveCurrent_019f14ce-ba22-78d7-a115-99da0afe555c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SettlementLiabilitiesCurrent_019f14ce-ba22-7be9-8e1b-f070acd118ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SettlementLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019f14ce-ba22-73f6-b1cc-fc83ec7acfa2" xlink:to="loc_us-gaap_SettlementLiabilitiesCurrent_019f14ce-ba22-7be9-8e1b-f070acd118ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#SupplementalFinancialInformationScheduleofOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019f3606-edd9-78a0-b324-03247fb755b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_019f3606-edd9-7e04-8e49-52222bcd8474" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019f3606-edd9-78a0-b324-03247fb755b7" xlink:to="loc_us-gaap_AccruedBonusesCurrent_019f3606-edd9-7e04-8e49-52222bcd8474" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AccruedSeveranceCurrent_019f3606-edd9-74eb-9c69-7d9a1714312b" xlink:href="wgs-20260630.xsd#wgs_AccruedSeveranceCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019f3606-edd9-78a0-b324-03247fb755b7" xlink:to="loc_wgs_AccruedSeveranceCurrent_019f3606-edd9-74eb-9c69-7d9a1714312b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesCurrent_019f3606-edd9-7c09-a861-b986936f6536" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherSundryLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019f3606-edd9-78a0-b324-03247fb755b7" xlink:to="loc_us-gaap_OtherSundryLiabilitiesCurrent_019f3606-edd9-7c09-a861-b986936f6536" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019f3606-edd9-731d-bbbf-0d4956c9002c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019f3606-edd9-78a0-b324-03247fb755b7" xlink:to="loc_us-gaap_LongTermDebtCurrent_019f3606-edd9-731d-bbbf-0d4956c9002c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_019f3606-edd9-7166-8849-1de35b185b9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019f3606-edd9-78a0-b324-03247fb755b7" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_019f3606-edd9-7166-8849-1de35b185b9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_WarrantLiabilityCurrent_019f3606-edd9-7b1d-8daf-83d2dfbb0877" xlink:href="wgs-20260630.xsd#wgs_WarrantLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019f3606-edd9-78a0-b324-03247fb755b7" xlink:to="loc_wgs_WarrantLiabilityCurrent_019f3606-edd9-7b1d-8daf-83d2dfbb0877" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofOtherLiabilitiesDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#SupplementalFinancialInformationScheduleofOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationScheduleofOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019f14ce-ba22-7199-9cf8-109b23fc7c85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_019f14ce-ba22-7fc8-b1c1-aae01d9b5fe9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019f14ce-ba22-7199-9cf8-109b23fc7c85" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_019f14ce-ba22-7fc8-b1c1-aae01d9b5fe9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesNoncurrent_019f14ce-ba22-73b5-a7e7-748f5fb02153" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherSundryLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019f14ce-ba22-7199-9cf8-109b23fc7c85" xlink:to="loc_us-gaap_OtherSundryLiabilitiesNoncurrent_019f14ce-ba22-73b5-a7e7-748f5fb02153" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SegmentReportingScheduleofSegmentReportingInformationDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#SegmentReportingScheduleofSegmentReportingInformationDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SegmentReportingScheduleofSegmentReportingInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fb1af-dfc2-74ac-8654-b6c8ee3f2117" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019fb1af-dfc2-7394-875a-63fab8f13002" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fb1af-dfc2-74ac-8654-b6c8ee3f2117" xlink:to="loc_us-gaap_GrossProfit_019fb1af-dfc2-7394-875a-63fab8f13002" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019fb1af-dfc2-728a-a98f-88cf109d12da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fb1af-dfc2-74ac-8654-b6c8ee3f2117" xlink:to="loc_us-gaap_OperatingExpenses_019fb1af-dfc2-728a-a98f-88cf109d12da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019fb1af-dfc2-7ce7-a9ba-471e11f2244d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fb1af-dfc2-74ac-8654-b6c8ee3f2117" xlink:to="loc_us-gaap_AssetImpairmentCharges_019fb1af-dfc2-7ce7-a9ba-471e11f2244d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019fb1ae-2ccd-7f76-b409-d6b6b7311b85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedGrossProfit_019fb1ae-2ccd-7950-a0a3-7030cfcf0cfb" xlink:href="wgs-20260630.xsd#wgs_AdjustedGrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fb1ae-2ccd-7f76-b409-d6b6b7311b85" xlink:to="loc_wgs_AdjustedGrossProfit_019fb1ae-2ccd-7950-a0a3-7030cfcf0cfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019fb1ae-2ccd-77b8-bdb1-cd5ef1558ad0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fb1ae-2ccd-7f76-b409-d6b6b7311b85" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019fb1ae-2ccd-77b8-bdb1-cd5ef1558ad0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fb1ae-2ccd-74b3-937e-6cce80c97786" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fb1ae-2ccd-7f76-b409-d6b6b7311b85" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fb1ae-2ccd-74b3-937e-6cce80c97786" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_019fb1ae-2ccd-783e-b085-ea5554afa69c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCosts"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fb1ae-2ccd-7f76-b409-d6b6b7311b85" xlink:to="loc_us-gaap_RestructuringCosts_019fb1ae-2ccd-783e-b085-ea5554afa69c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedGrossProfit_019fb1ad-dd74-7584-a143-9e8be2d05953" xlink:href="wgs-20260630.xsd#wgs_AdjustedGrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fb1ad-dd74-71c0-9228-9c6983d7737a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedGrossProfit_019fb1ad-dd74-7584-a143-9e8be2d05953" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fb1ad-dd74-71c0-9228-9c6983d7737a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedCostOfGoodSold_019fb1ad-dd74-754c-b12c-fca610808526" xlink:href="wgs-20260630.xsd#wgs_AdjustedCostOfGoodSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedGrossProfit_019fb1ad-dd74-7584-a143-9e8be2d05953" xlink:to="loc_wgs_AdjustedCostOfGoodSold_019fb1ad-dd74-754c-b12c-fca610808526" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SegmentReportingScheduleofAdjustedNetIncomeLossDetails" xlink:type="simple" xlink:href="wgs-20260630.xsd#SegmentReportingScheduleofAdjustedNetIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SegmentReportingScheduleofAdjustedNetIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:href="wgs-20260630.xsd#wgs_AdjustedNetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fb170-b0fc-7be2-bbdf-ccb7ce0e7487" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_NetIncomeLoss_019fb170-b0fc-7be2-bbdf-ccb7ce0e7487" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019fb170-b0fc-7668-a2a3-237ac2e4e089" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019fb170-b0fc-7668-a2a3-237ac2e4e089" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fb170-b0fc-7bfc-b3ac-60ed273c4a6a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fb170-b0fc-7bfc-b3ac-60ed273c4a6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_019fb170-b0fc-77eb-8291-e9205e14bcb9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCosts"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_RestructuringCosts_019fb170-b0fc-77eb-8291-e9205e14bcb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities_019fb170-b0fc-75b3-8c81-c4382d2a168b" xlink:href="wgs-20260630.xsd#wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities_019fb170-b0fc-75b3-8c81-c4382d2a168b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019fb170-b0fc-7158-9ae4-69f3e3504c1d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019fb170-b0fc-7158-9ae4-69f3e3504c1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_NonCoreLeaseCosts_019fb170-b0fc-707a-ae7f-7c367a0f67e8" xlink:href="wgs-20260630.xsd#wgs_NonCoreLeaseCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_wgs_NonCoreLeaseCosts_019fb170-b0fc-707a-ae7f-7c367a0f67e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019fb170-b0fc-7ff1-8217-e0925ba81c1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_AssetImpairmentCharges_019fb170-b0fc-7ff1-8217-e0925ba81c1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019fb170-b0fc-7dc2-8a2d-e8722966d576" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019fb170-b0fc-7dc2-8a2d-e8722966d576" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fb170-b0fc-73b9-b4ce-fa80e32380cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_wgs_AdjustedNetIncomeLoss_019fb170-b0fc-746f-bf8c-6d260fb291d5" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fb170-b0fc-73b9-b4ce-fa80e32380cc" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
