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  <xs:element id="wgs_CreditAgreementTrancheBLoanMember" abstract="true" name="CreditAgreementTrancheBLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_January2023PublicOfferingMember" abstract="true" name="January2023PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="wgs_January2023AdditionalPurchaseOfferingMember" abstract="true" name="January2023AdditionalPurchaseOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="wgs_CumulativeFunding" abstract="false" name="CumulativeFunding" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_BioReferenceLaboratoriesIncMember" abstract="true" name="BioReferenceLaboratoriesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wgs_DebtInstrumentFundingCommitment" abstract="false" name="DebtInstrumentFundingCommitment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_PayorBMember" abstract="true" name="PayorBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="wgs_RemainingNumberOfCommonStockSharesIssued" abstract="false" name="RemainingNumberOfCommonStockSharesIssued" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisableAfterTermOfAwardNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisableAfterTermOfAwardNumber" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="wgs_ChangeInThirdPartyPayorReserves" abstract="false" name="ChangeInThirdPartyPayorReserves" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_LegacySema4Member" abstract="true" name="LegacySema4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="wgs_PayorAMember" abstract="true" name="PayorAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="wgs_SoftwareDevelopmentCostsIncurredButNotYetPaid" abstract="false" name="SoftwareDevelopmentCostsIncurredButNotYetPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_BuildingHeldUnderFinanceLeaseMember" abstract="true" name="BuildingHeldUnderFinanceLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="wgs_WarrantLiability" abstract="false" name="WarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wgs_AdjustedCostOfGoodSold" abstract="false" name="AdjustedCostOfGoodSold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
