<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:a428155e-89c7-4d91-a72e-64b9c9b966ac,g:621bb203-1cff-496f-a648-11fa349f21e9-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.genedx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="wgs-20240331.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_b6db05d7-a584-4bf9-bd7c-a3ab3e2c53f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7b54ebea-1e03-4a1e-92bf-80fea99fef98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b6db05d7-a584-4bf9-bd7c-a3ab3e2c53f8" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7b54ebea-1e03-4a1e-92bf-80fea99fef98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseLiabilitiesCurrent_657cd75b-239f-49ac-bff7-090067028f0a" xlink:href="wgs-20240331.xsd#wgs_LeaseLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b6db05d7-a584-4bf9-bd7c-a3ab3e2c53f8" xlink:to="loc_wgs_LeaseLiabilitiesCurrent_657cd75b-239f-49ac-bff7-090067028f0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_707a1551-6cd3-4b30-a8d4-6d3f7b5977e2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b6db05d7-a584-4bf9-bd7c-a3ab3e2c53f8" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_707a1551-6cd3-4b30-a8d4-6d3f7b5977e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7bfffa39-e25e-47a8-8e9b-be2bf5724097" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b878effe-4ccd-419f-b5d8-66425c6ba7db" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7bfffa39-e25e-47a8-8e9b-be2bf5724097" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b878effe-4ccd-419f-b5d8-66425c6ba7db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_d528429d-2b2b-4a39-beb3-c9f973a2c2ac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7bfffa39-e25e-47a8-8e9b-be2bf5724097" xlink:to="loc_us-gaap_AdditionalPaidInCapital_d528429d-2b2b-4a39-beb3-c9f973a2c2ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_18aa832d-7511-4240-ab87-a63eaf66a911" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7bfffa39-e25e-47a8-8e9b-be2bf5724097" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_18aa832d-7511-4240-ab87-a63eaf66a911" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_91334924-d078-400e-a29f-ab8f0fd213f6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7bfffa39-e25e-47a8-8e9b-be2bf5724097" xlink:to="loc_us-gaap_PreferredStockValue_91334924-d078-400e-a29f-ab8f0fd213f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_fc380202-e52b-40ef-931e-b90d11438ad9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7bfffa39-e25e-47a8-8e9b-be2bf5724097" xlink:to="loc_us-gaap_CommonStockValue_fc380202-e52b-40ef-931e-b90d11438ad9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_be0b5580-7014-4c25-a794-816551fb3ff8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_2a2d749c-2b5f-4cf2-a082-5c356598d756" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_be0b5580-7014-4c25-a794-816551fb3ff8" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_2a2d749c-2b5f-4cf2-a082-5c356598d756" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_ed5151f0-b5ec-4a8b-b8a6-22dc765fa380" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_be0b5580-7014-4c25-a794-816551fb3ff8" xlink:to="loc_us-gaap_LiabilitiesCurrent_ed5151f0-b5ec-4a8b-b8a6-22dc765fa380" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_2ea788f4-fe9f-4c7f-af49-cdb807b16c90" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_be0b5580-7014-4c25-a794-816551fb3ff8" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_2ea788f4-fe9f-4c7f-af49-cdb807b16c90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_aefe37e7-2bb2-4d40-b090-80c243a2abec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_be0b5580-7014-4c25-a794-816551fb3ff8" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_aefe37e7-2bb2-4d40-b090-80c243a2abec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseLiabilitiesNoncurrent_c5d7f28b-7157-4255-86b9-75b74fa3457a" xlink:href="wgs-20240331.xsd#wgs_LeaseLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_be0b5580-7014-4c25-a794-816551fb3ff8" xlink:to="loc_wgs_LeaseLiabilitiesNoncurrent_c5d7f28b-7157-4255-86b9-75b74fa3457a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_7b809d13-e792-47be-9f8c-d5767b8c61ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_5a693bd4-580b-4790-84ce-cee613dd6ff5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7b809d13-e792-47be-9f8c-d5767b8c61ec" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_5a693bd4-580b-4790-84ce-cee613dd6ff5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0ff83b93-810d-4f36-ac2c-075678564d81" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7b809d13-e792-47be-9f8c-d5767b8c61ec" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0ff83b93-810d-4f36-ac2c-075678564d81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_b230ed86-5864-480e-99c4-99406bbe6c72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7b809d13-e792-47be-9f8c-d5767b8c61ec" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_b230ed86-5864-480e-99c4-99406bbe6c72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_4443d8e7-bd93-49a5-a5f6-606c6e5fed09" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7b809d13-e792-47be-9f8c-d5767b8c61ec" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_4443d8e7-bd93-49a5-a5f6-606c6e5fed09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_fc672207-c870-4542-a206-42c75099c0e7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7b809d13-e792-47be-9f8c-d5767b8c61ec" xlink:to="loc_us-gaap_InventoryNet_fc672207-c870-4542-a206-42c75099c0e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2d204ae-39ef-407e-9675-34f70ea55586" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_8036cfb6-6100-45ac-b968-dcfb56a01c06" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2d204ae-39ef-407e-9675-34f70ea55586" xlink:to="loc_us-gaap_Liabilities_8036cfb6-6100-45ac-b968-dcfb56a01c06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_95ff516c-81b3-4456-b680-2196971e896a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2d204ae-39ef-407e-9675-34f70ea55586" xlink:to="loc_us-gaap_StockholdersEquity_95ff516c-81b3-4456-b680-2196971e896a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_fbdb6b0c-bf8f-4500-baa4-13fd77c9cd42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2d204ae-39ef-407e-9675-34f70ea55586" xlink:to="loc_us-gaap_CommitmentsAndContingencies_fbdb6b0c-bf8f-4500-baa4-13fd77c9cd42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_25b854ca-eddc-4ae9-910f-ce29b98a989a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_35e715e5-3dd2-40ec-a968-10575e5e8825" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_25b854ca-eddc-4ae9-910f-ce29b98a989a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_35e715e5-3dd2-40ec-a968-10575e5e8825" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_6905f1ad-43f1-4352-bc09-628507e92e21" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_25b854ca-eddc-4ae9-910f-ce29b98a989a" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_6905f1ad-43f1-4352-bc09-628507e92e21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_819af860-169c-43da-aa28-485b1828e82a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_25b854ca-eddc-4ae9-910f-ce29b98a989a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_819af860-169c-43da-aa28-485b1828e82a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_37e857d4-92ea-4cce-af34-13779567cb19" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_25b854ca-eddc-4ae9-910f-ce29b98a989a" xlink:to="loc_us-gaap_AssetsCurrent_37e857d4-92ea-4cce-af34-13779567cb19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_592e6d92-6da2-44e3-8295-561c9caaa5ad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_25b854ca-eddc-4ae9-910f-ce29b98a989a" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_592e6d92-6da2-44e3-8295-561c9caaa5ad" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossUnaudited" xlink:type="simple" xlink:href="wgs-20240331.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLossUnaudited"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a10f51c9-667c-4279-81ef-32289b842d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_6719367f-bbd2-4ccd-a88d-70c8ea3c83cd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a10f51c9-667c-4279-81ef-32289b842d2d" xlink:to="loc_us-gaap_OperatingIncomeLoss_6719367f-bbd2-4ccd-a88d-70c8ea3c83cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_ccd04739-4820-47cc-a0c7-732033555e0c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a10f51c9-667c-4279-81ef-32289b842d2d" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_ccd04739-4820-47cc-a0c7-732033555e0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_35526ee1-dc8a-41ba-8217-969c3e650517" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_932f1641-cce2-4cdd-9f27-748f34e9418c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_35526ee1-dc8a-41ba-8217-969c3e650517" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_932f1641-cce2-4cdd-9f27-748f34e9418c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_e80d7dcd-9783-4a10-8b96-693667f1d7fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_35526ee1-dc8a-41ba-8217-969c3e650517" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_e80d7dcd-9783-4a10-8b96-693667f1d7fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_45ae81ca-207e-4fc5-8cca-111ff95ca376" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_35526ee1-dc8a-41ba-8217-969c3e650517" xlink:to="loc_us-gaap_GrossProfit_45ae81ca-207e-4fc5-8cca-111ff95ca376" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_74f725f3-1eeb-4c37-9c19-d5103e217385" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_35526ee1-dc8a-41ba-8217-969c3e650517" xlink:to="loc_us-gaap_SellingAndMarketingExpense_74f725f3-1eeb-4c37-9c19-d5103e217385" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_171d89e9-bdbd-450f-b336-f95a4c5e4542" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_35526ee1-dc8a-41ba-8217-969c3e650517" xlink:to="loc_us-gaap_AssetImpairmentCharges_171d89e9-bdbd-450f-b336-f95a4c5e4542" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_4de8c704-9fb4-4ee1-aa19-687ba5a2882b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_35526ee1-dc8a-41ba-8217-969c3e650517" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_4de8c704-9fb4-4ee1-aa19-687ba5a2882b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_303e7fde-b99d-41b9-b7b2-b3b4cea6485d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_3eeac52a-a11f-411b-94c4-0c8e413aaf23" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_303e7fde-b99d-41b9-b7b2-b3b4cea6485d" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_3eeac52a-a11f-411b-94c4-0c8e413aaf23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_3d6d9519-09d1-4a31-800a-7e5d8948b758" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_303e7fde-b99d-41b9-b7b2-b3b4cea6485d" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_3d6d9519-09d1-4a31-800a-7e5d8948b758" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities_c858438f-de76-4195-918c-f33cd844e24f" xlink:href="wgs-20240331.xsd#wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_303e7fde-b99d-41b9-b7b2-b3b4cea6485d" xlink:to="loc_wgs_ChangeInFairValueOfWarrantsAndEarnOutContingentLiabilities_c858438f-de76-4195-918c-f33cd844e24f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_5eb1c51d-cefa-41d4-8389-ca20a4e77b75" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_9591abe1-7c2e-45c4-8b6a-437d7ba4103a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_5eb1c51d-cefa-41d4-8389-ca20a4e77b75" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_9591abe1-7c2e-45c4-8b6a-437d7ba4103a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_59a21f1d-518f-4814-a611-282d6f97799f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_5eb1c51d-cefa-41d4-8389-ca20a4e77b75" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_59a21f1d-518f-4814-a611-282d6f97799f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8c3b09fc-6ba9-4683-8d57-03971e26280b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_81be5a81-4d4d-4e3e-93f1-49bceac88680" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_8c3b09fc-6ba9-4683-8d57-03971e26280b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_81be5a81-4d4d-4e3e-93f1-49bceac88680" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f644ade5-1fe3-41b3-9cc4-f7dfbdbbe144" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_8c3b09fc-6ba9-4683-8d57-03971e26280b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f644ade5-1fe3-41b3-9cc4-f7dfbdbbe144" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_46676c3b-165e-48b9-9d07-54d85d4ff8f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_b26fac5d-50dd-4acd-b129-3af7c5d54c68" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_46676c3b-165e-48b9-9d07-54d85d4ff8f2" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_b26fac5d-50dd-4acd-b129-3af7c5d54c68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d91f79e4-36d4-4e4e-8929-234b5e61e86d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_46676c3b-165e-48b9-9d07-54d85d4ff8f2" xlink:to="loc_us-gaap_NetIncomeLoss_d91f79e4-36d4-4e4e-8929-234b5e61e86d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="wgs-20240331.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a4883cf7-09c6-4031-916d-0f794414af97" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_29b3e147-4a37-42bf-a875-1a3d92e10bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a4883cf7-09c6-4031-916d-0f794414af97" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_29b3e147-4a37-42bf-a875-1a3d92e10bd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarlyRepaymentOfSeniorDebt_0e3c6780-bc00-412b-9f54-380c1a6477e2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarlyRepaymentOfSeniorDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a4883cf7-09c6-4031-916d-0f794414af97" xlink:to="loc_us-gaap_EarlyRepaymentOfSeniorDebt_0e3c6780-bc00-412b-9f54-380c1a6477e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_8776cf6e-f625-47cd-a11c-ee930ed8919f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a4883cf7-09c6-4031-916d-0f794414af97" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_8776cf6e-f625-47cd-a11c-ee930ed8919f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_ffa2d14f-cc53-4e0b-8161-18be199ee312" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a4883cf7-09c6-4031-916d-0f794414af97" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_ffa2d14f-cc53-4e0b-8161-18be199ee312" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3c044bf8-eac9-4213-990c-554e2d94ea1c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_012beb43-a8ef-45ec-8c7f-97169d7b0559" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3c044bf8-eac9-4213-990c-554e2d94ea1c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_012beb43-a8ef-45ec-8c7f-97169d7b0559" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_729d7d12-0826-4158-a61c-51a82fcadf57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3c044bf8-eac9-4213-990c-554e2d94ea1c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_729d7d12-0826-4158-a61c-51a82fcadf57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_dc799de8-0416-4414-81af-3db12cc0a2ca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3c044bf8-eac9-4213-990c-554e2d94ea1c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_dc799de8-0416-4414-81af-3db12cc0a2ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6ea18679-73d3-4673-83ff-5ee1541782b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToDevelopSoftware_73d1d1f7-bc17-42a9-914b-3eb860abfbf7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToDevelopSoftware"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6ea18679-73d3-4673-83ff-5ee1541782b1" xlink:to="loc_us-gaap_PaymentsToDevelopSoftware_73d1d1f7-bc17-42a9-914b-3eb860abfbf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_52416d42-ab4d-4d92-97d3-5d697fef1bbd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6ea18679-73d3-4673-83ff-5ee1541782b1" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_52416d42-ab4d-4d92-97d3-5d697fef1bbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_14c38883-6346-44d9-b119-62b9ad447ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6ea18679-73d3-4673-83ff-5ee1541782b1" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_14c38883-6346-44d9-b119-62b9ad447ce8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_46736952-8896-437d-9e81-978a8f9e6b87" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6ea18679-73d3-4673-83ff-5ee1541782b1" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_46736952-8896-437d-9e81-978a8f9e6b87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_31f25f31-e9b5-4e08-899c-e7a75cd6e2f0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6ea18679-73d3-4673-83ff-5ee1541782b1" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_31f25f31-e9b5-4e08-899c-e7a75cd6e2f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_fb28b5ae-4a9f-4342-8440-c84e65894269" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_NetIncomeLoss_fb28b5ae-4a9f-4342-8440-c84e65894269" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_cc543fcd-cbca-4223-a57f-99a899378e9e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_cc543fcd-cbca-4223-a57f-99a899378e9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ChangeInThirdPartyPayorReserves_a268b3df-a307-4849-9116-447927943cbc" xlink:href="wgs-20240331.xsd#wgs_ChangeInThirdPartyPayorReserves"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_wgs_ChangeInThirdPartyPayorReserves_a268b3df-a307-4849-9116-447927943cbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_14a4683e-b655-4e5b-a8c8-3ed9f56a3e69" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_14a4683e-b655-4e5b-a8c8-3ed9f56a3e69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_247e531f-dccf-479c-aea1-b76ab7c348fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_247e531f-dccf-479c-aea1-b76ab7c348fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_118a2bf1-6d2b-4d55-88e1-5daa7c87ef56" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_118a2bf1-6d2b-4d55-88e1-5daa7c87ef56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_GainLossOnDebtForgiveness_581b8455-ba7b-4e05-9c65-f16d2f0206ab" xlink:href="wgs-20240331.xsd#wgs_GainLossOnDebtForgiveness"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_wgs_GainLossOnDebtForgiveness_581b8455-ba7b-4e05-9c65-f16d2f0206ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_3875d9fe-94d7-4e5f-b3bf-d37fa056cbb4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_AssetImpairmentCharges_3875d9fe-94d7-4e5f-b3bf-d37fa056cbb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_fb090135-ac56-45f7-9c39-b549f80d2e0c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_ShareBasedCompensation_fb090135-ac56-45f7-9c39-b549f80d2e0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_64350f7a-0ddb-4a88-8295-77728fa6b4b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_64350f7a-0ddb-4a88-8295-77728fa6b4b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_e2eec830-c0f0-4087-8d55-b298b9eb34af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_e2eec830-c0f0-4087-8d55-b298b9eb34af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_cae2b71c-9905-4847-978b-f1d8cc5e278c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_cae2b71c-9905-4847-978b-f1d8cc5e278c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_1ee6f0de-1c9e-485a-b689-d63b10affa85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_InventoryWriteDown_1ee6f0de-1c9e-485a-b689-d63b10affa85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_a90514c4-afa7-4093-a969-543b97fff55b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eac2703c-fc66-4b7c-9074-88decffbad0e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_a90514c4-afa7-4093-a969-543b97fff55b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/FairValueMeasurementsScheduleofFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#FairValueMeasurementsScheduleofFairValueonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/FairValueMeasurementsScheduleofFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_9748e91a-1e37-410c-a8ea-6a1a4e3a14bf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_71c9f35a-75c1-4f72-a460-066e14a2d76e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_9748e91a-1e37-410c-a8ea-6a1a4e3a14bf" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_71c9f35a-75c1-4f72-a460-066e14a2d76e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_7a6eed26-8708-454d-adf9-4b139802e2b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_213358ec-c93f-412f-8223-0453f1530986" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_7a6eed26-8708-454d-adf9-4b139802e2b3" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_213358ec-c93f-412f-8223-0453f1530986" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/PropertyandEquipmentnetComponentsDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#PropertyandEquipmentnetComponentsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/PropertyandEquipmentnetComponentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_a34645e6-63fc-4787-ba2a-548c783460be" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_684e4aaa-8f39-4848-967e-837d3f1c9fa8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_a34645e6-63fc-4787-ba2a-548c783460be" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_684e4aaa-8f39-4848-967e-837d3f1c9fa8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_35851459-e2b2-40bd-b761-d2bdfebccbd8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_a34645e6-63fc-4787-ba2a-548c783460be" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_35851459-e2b2-40bd-b761-d2bdfebccbd8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/IntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#IntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/IntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_67cdf00c-1233-433e-bc36-b0446551a87c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_51b78fa0-5843-4175-822c-411283d489de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_67cdf00c-1233-433e-bc36-b0446551a87c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_51b78fa0-5843-4175-822c-411283d489de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_c5c1baa2-32d8-49ec-b02c-f05001f606e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_67cdf00c-1233-433e-bc36-b0446551a87c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_c5c1baa2-32d8-49ec-b02c-f05001f606e0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/RelatedPartyTransactionsRelatedPartyCostsDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#RelatedPartyTransactionsRelatedPartyCostsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/RelatedPartyTransactionsRelatedPartyCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_cbda4b01-cea5-4415-b0d2-2be2a666791e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_e5aa578f-5044-4653-be02-b4695a63ffed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_cbda4b01-cea5-4415-b0d2-2be2a666791e" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_e5aa578f-5044-4653-be02-b4695a63ffed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_8dfb2c45-2419-4476-bf3e-f2ddd0f24ae8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_cbda4b01-cea5-4415-b0d2-2be2a666791e" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_8dfb2c45-2419-4476-bf3e-f2ddd0f24ae8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/LongTermDebtScheduleofLongTermDebtMaturitiesDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#LongTermDebtScheduleofLongTermDebtMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/LongTermDebtScheduleofLongTermDebtMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_a2145a2b-d953-47f9-acc1-cf6d9f3741f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_6acc0957-5445-435d-b50e-5f6e65687bc5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a2145a2b-d953-47f9-acc1-cf6d9f3741f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_6acc0957-5445-435d-b50e-5f6e65687bc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_d899d04b-4c9f-4d76-8250-639c2f87f499" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a2145a2b-d953-47f9-acc1-cf6d9f3741f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_d899d04b-4c9f-4d76-8250-639c2f87f499" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LongTermDebtMaturityAfterYearFour_9afce011-b72d-4a96-b519-4759595a1c67" xlink:href="wgs-20240331.xsd#wgs_LongTermDebtMaturityAfterYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a2145a2b-d953-47f9-acc1-cf6d9f3741f4" xlink:to="loc_wgs_LongTermDebtMaturityAfterYearFour_9afce011-b72d-4a96-b519-4759595a1c67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_dfc199b8-7809-478c-876b-0c39c9a481d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a2145a2b-d953-47f9-acc1-cf6d9f3741f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_dfc199b8-7809-478c-876b-0c39c9a481d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_de6bc632-10be-4229-9ca3-31ddf462ff84" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a2145a2b-d953-47f9-acc1-cf6d9f3741f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_de6bc632-10be-4229-9ca3-31ddf462ff84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_24efd9c3-fd34-4637-a7be-1e3c5ffe7f3c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a2145a2b-d953-47f9-acc1-cf6d9f3741f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_24efd9c3-fd34-4637-a7be-1e3c5ffe7f3c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligation_6cbfdb8a-febf-4419-8976-55b5557369d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_fc70c47d-e024-43f3-a163-7eddd0cd8ef8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligationDueInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_6cbfdb8a-febf-4419-8976-55b5557369d9" xlink:to="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_fc70c47d-e024-43f3-a163-7eddd0cd8ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationFutureMinimumPaymentsRemainderOfFiscalYear_d300472e-ebd9-42ed-852e-6440ad0acee9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligationFutureMinimumPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_6cbfdb8a-febf-4419-8976-55b5557369d9" xlink:to="loc_us-gaap_PurchaseObligationFutureMinimumPaymentsRemainderOfFiscalYear_d300472e-ebd9-42ed-852e-6440ad0acee9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInFourthYear_4a30bcd8-cb4a-4c3e-9113-734184f2bb73" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligationDueInFourthYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_6cbfdb8a-febf-4419-8976-55b5557369d9" xlink:to="loc_us-gaap_PurchaseObligationDueInFourthYear_4a30bcd8-cb4a-4c3e-9113-734184f2bb73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInSecondYear_31fb478c-38ba-44fe-8181-b2fa1e6a227f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligationDueInSecondYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_6cbfdb8a-febf-4419-8976-55b5557369d9" xlink:to="loc_us-gaap_PurchaseObligationDueInSecondYear_31fb478c-38ba-44fe-8181-b2fa1e6a227f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInThirdYear_746c0da1-bd0b-478f-b878-0b4ccb690bc1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligationDueInThirdYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_6cbfdb8a-febf-4419-8976-55b5557369d9" xlink:to="loc_us-gaap_PurchaseObligationDueInThirdYear_746c0da1-bd0b-478f-b878-0b4ccb690bc1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/NetLossperShareDilutedDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#NetLossperShareDilutedDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/NetLossperShareDilutedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_b9f4e417-8355-49cc-b0b9-92bf6fd47e05" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2a960b8f-be85-47b6-91ad-c68f5db75b00" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_b9f4e417-8355-49cc-b0b9-92bf6fd47e05" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2a960b8f-be85-47b6-91ad-c68f5db75b00" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationCashCashEquivalentsAndRestrictedCashDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#SupplementalFinancialInformationCashCashEquivalentsAndRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationCashCashEquivalentsAndRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_53bae642-fe49-4a1e-bcee-41a1d7fecd58" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_19ee3dfb-560a-4047-9a6e-8656a18e79b6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_53bae642-fe49-4a1e-bcee-41a1d7fecd58" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_19ee3dfb-560a-4047-9a6e-8656a18e79b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_4677c917-f20e-4b7b-a514-20b757def8fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_53bae642-fe49-4a1e-bcee-41a1d7fecd58" xlink:to="loc_us-gaap_RestrictedCash_4677c917-f20e-4b7b-a514-20b757def8fb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationAccountsPayableandAccruedExpensesDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#SupplementalFinancialInformationAccountsPayableandAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationAccountsPayableandAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_432dd270-b79b-4a54-a381-7e89f65ec01c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_d1f3ed11-c281-427b-bf9f-dbca97727aca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_432dd270-b79b-4a54-a381-7e89f65ec01c" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_d1f3ed11-c281-427b-bf9f-dbca97727aca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_7dc72dd2-6e23-4392-8464-bfa03ce14529" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_432dd270-b79b-4a54-a381-7e89f65ec01c" xlink:to="loc_us-gaap_AccountsPayableCurrent_7dc72dd2-6e23-4392-8464-bfa03ce14529" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedInsuranceCurrent_70166bc1-2f30-4959-8c0c-4cc48c1a4033" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedInsuranceCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_432dd270-b79b-4a54-a381-7e89f65ec01c" xlink:to="loc_us-gaap_AccruedInsuranceCurrent_70166bc1-2f30-4959-8c0c-4cc48c1a4033" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#SupplementalFinancialInformationOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_41511567-6a9d-4aa4-9098-556a9863bca4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_5a518188-b694-46fe-a12b-09a23357e4e2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_41511567-6a9d-4aa4-9098-556a9863bca4" xlink:to="loc_us-gaap_AccruedBonusesCurrent_5a518188-b694-46fe-a12b-09a23357e4e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesCurrent_0be48b8b-6111-4ac8-938e-1c4263069b78" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherSundryLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_41511567-6a9d-4aa4-9098-556a9863bca4" xlink:to="loc_us-gaap_OtherSundryLiabilitiesCurrent_0be48b8b-6111-4ac8-938e-1c4263069b78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AccruedSeveranceCurrent_b516371c-7fa7-47ef-8dd4-5a3d58f4df42" xlink:href="wgs-20240331.xsd#wgs_AccruedSeveranceCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_41511567-6a9d-4aa4-9098-556a9863bca4" xlink:to="loc_wgs_AccruedSeveranceCurrent_b516371c-7fa7-47ef-8dd4-5a3d58f4df42" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationOtherLiabilitiesDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#SupplementalFinancialInformationOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_32018553-8197-4524-b59f-c46624b0eaad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_WarrantLiability_d8c45c81-a350-48b7-b721-db9700cade12" xlink:href="wgs-20240331.xsd#wgs_WarrantLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_32018553-8197-4524-b59f-c46624b0eaad" xlink:to="loc_wgs_WarrantLiability_d8c45c81-a350-48b7-b721-db9700cade12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ThirdPartyPayorReserveNonCurrent_bb5c290b-583a-4ef7-a48c-c7dd856efa62" xlink:href="wgs-20240331.xsd#wgs_ThirdPartyPayorReserveNonCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_32018553-8197-4524-b59f-c46624b0eaad" xlink:to="loc_wgs_ThirdPartyPayorReserveNonCurrent_bb5c290b-583a-4ef7-a48c-c7dd856efa62" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SegmentReportingScheduleofSegmentReportingInformationDetails" xlink:type="simple" xlink:href="wgs-20240331.xsd#SegmentReportingScheduleofSegmentReportingInformationDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SegmentReportingScheduleofSegmentReportingInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedGrossMargin_99b7b991-da63-4dda-b9e0-01137977485e" xlink:href="wgs-20240331.xsd#wgs_AdjustedGrossMargin"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedCostOfGoodSold_3cab3c15-c28f-43af-9796-9eba12d4267a" xlink:href="wgs-20240331.xsd#wgs_AdjustedCostOfGoodSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_AdjustedGrossMargin_99b7b991-da63-4dda-b9e0-01137977485e" xlink:to="loc_wgs_AdjustedCostOfGoodSold_3cab3c15-c28f-43af-9796-9eba12d4267a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0f9b45c6-e461-4c33-9570-5c44725430bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_AdjustedGrossMargin_99b7b991-da63-4dda-b9e0-01137977485e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0f9b45c6-e461-4c33-9570-5c44725430bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_4bec2825-e15a-47fb-887d-c0b342b428f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedGrossMargin_b6713b51-f2b2-41aa-b3eb-063c2ef087c1" xlink:href="wgs-20240331.xsd#wgs_AdjustedGrossMargin"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_4bec2825-e15a-47fb-887d-c0b342b428f2" xlink:to="loc_wgs_AdjustedGrossMargin_b6713b51-f2b2-41aa-b3eb-063c2ef087c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_ce102d69-9ddc-4bfa-a58c-0dbf0665823f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestructuringCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_4bec2825-e15a-47fb-887d-c0b342b428f2" xlink:to="loc_us-gaap_RestructuringCosts_ce102d69-9ddc-4bfa-a58c-0dbf0665823f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_c652be7c-224c-4059-ba88-c4e053222723" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_4bec2825-e15a-47fb-887d-c0b342b428f2" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_c652be7c-224c-4059-ba88-c4e053222723" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_d35a697e-1bc4-41c3-b9cb-480759bf1816" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_4bec2825-e15a-47fb-887d-c0b342b428f2" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_d35a697e-1bc4-41c3-b9cb-480759bf1816" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
