<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:016e7056-6f47-4dcf-92d2-fb921dc328fe,g:3ed167cd-c853-4b13-9a6c-6d563d8461c6-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.genedx.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="wgs-20231231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_8772b199-14bb-4127-b20c-1ac83713459a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_36e49cea-7b16-4489-b820-c5c3a99eeb01" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8772b199-14bb-4127-b20c-1ac83713459a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_36e49cea-7b16-4489-b820-c5c3a99eeb01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_cd56314f-ff1c-4244-b25a-3e7444e7ebf3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8772b199-14bb-4127-b20c-1ac83713459a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_cd56314f-ff1c-4244-b25a-3e7444e7ebf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_42bbcf82-f274-409e-8008-97fdb9037d9a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8772b199-14bb-4127-b20c-1ac83713459a" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_42bbcf82-f274-409e-8008-97fdb9037d9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_06c669e8-d427-4529-97f5-aee96d6e93bc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8772b199-14bb-4127-b20c-1ac83713459a" xlink:to="loc_us-gaap_AssetsCurrent_06c669e8-d427-4529-97f5-aee96d6e93bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_379eee9c-9041-4e70-95d0-e3f19100eaaa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8772b199-14bb-4127-b20c-1ac83713459a" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_379eee9c-9041-4e70-95d0-e3f19100eaaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_afad5b7b-833e-4b5d-b5d6-399981a4bec9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_88394710-1798-4ee3-8c3e-5426f28a1f00" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_afad5b7b-833e-4b5d-b5d6-399981a4bec9" xlink:to="loc_us-gaap_CommitmentsAndContingencies_88394710-1798-4ee3-8c3e-5426f28a1f00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_37834aae-3cce-4741-bea3-7cc2221fcd22" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_afad5b7b-833e-4b5d-b5d6-399981a4bec9" xlink:to="loc_us-gaap_StockholdersEquity_37834aae-3cce-4741-bea3-7cc2221fcd22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_00766a1b-daa9-4901-a54a-63eae84f7e48" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_afad5b7b-833e-4b5d-b5d6-399981a4bec9" xlink:to="loc_us-gaap_Liabilities_00766a1b-daa9-4901-a54a-63eae84f7e48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_40ea5f4a-ba04-4cfd-bebf-a6d82c29812d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_d05af56c-4d04-4e8b-9e5c-d8e020d107df" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_40ea5f4a-ba04-4cfd-bebf-a6d82c29812d" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_d05af56c-4d04-4e8b-9e5c-d8e020d107df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseLiabilitiesNoncurrent_91eedc27-c2a2-41af-89b1-cc35e461e9fc" xlink:href="wgs-20231231.xsd#wgs_LeaseLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_40ea5f4a-ba04-4cfd-bebf-a6d82c29812d" xlink:to="loc_wgs_LeaseLiabilitiesNoncurrent_91eedc27-c2a2-41af-89b1-cc35e461e9fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_8e7e3c98-b2c2-4374-888e-f32536977763" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_40ea5f4a-ba04-4cfd-bebf-a6d82c29812d" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_8e7e3c98-b2c2-4374-888e-f32536977763" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_aca0adbe-ba8a-4536-b944-045e6d315749" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_40ea5f4a-ba04-4cfd-bebf-a6d82c29812d" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_aca0adbe-ba8a-4536-b944-045e6d315749" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_2dc79ecf-5a63-432f-ad7d-575d47a31180" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_40ea5f4a-ba04-4cfd-bebf-a6d82c29812d" xlink:to="loc_us-gaap_LiabilitiesCurrent_2dc79ecf-5a63-432f-ad7d-575d47a31180" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_d547d987-bc3a-4512-b15c-4d4bab21c0d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_fa4b7e13-39f9-4bbe-a0fd-6d7de1938602" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d547d987-bc3a-4512-b15c-4d4bab21c0d0" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_fa4b7e13-39f9-4bbe-a0fd-6d7de1938602" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6b912f67-1bc9-4d30-9039-1d2c4b6b19ff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d547d987-bc3a-4512-b15c-4d4bab21c0d0" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6b912f67-1bc9-4d30-9039-1d2c4b6b19ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_318646d2-faf1-478e-85eb-a0f63362472f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d547d987-bc3a-4512-b15c-4d4bab21c0d0" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_318646d2-faf1-478e-85eb-a0f63362472f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_aefdfb0d-e2fa-4b87-a9b4-e65f21de6ad1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d547d987-bc3a-4512-b15c-4d4bab21c0d0" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_aefdfb0d-e2fa-4b87-a9b4-e65f21de6ad1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_bdb7aba7-a999-4ce7-8bf4-f3eedd92254b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d547d987-bc3a-4512-b15c-4d4bab21c0d0" xlink:to="loc_us-gaap_InventoryNet_bdb7aba7-a999-4ce7-8bf4-f3eedd92254b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c2d3bd69-5c56-462d-89ed-1b14384f17f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_f1745a22-62d4-4a02-b75f-3a4870d14f84" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2d3bd69-5c56-462d-89ed-1b14384f17f2" xlink:to="loc_us-gaap_CommonStockValue_f1745a22-62d4-4a02-b75f-3a4870d14f84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_8bf72a98-c9a0-4c49-8a6a-63949b12eb2d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2d3bd69-5c56-462d-89ed-1b14384f17f2" xlink:to="loc_us-gaap_PreferredStockValue_8bf72a98-c9a0-4c49-8a6a-63949b12eb2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_1ed89856-fe45-43ee-9634-612ae66ea227" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2d3bd69-5c56-462d-89ed-1b14384f17f2" xlink:to="loc_us-gaap_AdditionalPaidInCapital_1ed89856-fe45-43ee-9634-612ae66ea227" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5b377eae-3f2c-47b3-b3bc-0a14a64a28f5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2d3bd69-5c56-462d-89ed-1b14384f17f2" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_5b377eae-3f2c-47b3-b3bc-0a14a64a28f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3ff68c35-b721-4975-9855-9a0bf668e714" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2d3bd69-5c56-462d-89ed-1b14384f17f2" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3ff68c35-b721-4975-9855-9a0bf668e714" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_4e566c9a-938c-4470-930d-5bb6bc30aeec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseLiabilitiesCurrent_a55a2daa-8749-4280-983e-b86af7ec9cb5" xlink:href="wgs-20231231.xsd#wgs_LeaseLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_4e566c9a-938c-4470-930d-5bb6bc30aeec" xlink:to="loc_wgs_LeaseLiabilitiesCurrent_a55a2daa-8749-4280-983e-b86af7ec9cb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_24f02d78-e500-4026-b541-ca44a5c4eec7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_4e566c9a-938c-4470-930d-5bb6bc30aeec" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_24f02d78-e500-4026-b541-ca44a5c4eec7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_753b432f-6542-42c7-8f7c-9ecb78464007" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_4e566c9a-938c-4470-930d-5bb6bc30aeec" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_753b432f-6542-42c7-8f7c-9ecb78464007" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="wgs-20231231.xsd#ConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_6113eb94-3bd9-43ca-84f3-536f6c65d35f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_894a7ec9-6fe7-4bbe-92fe-56ccc934fdfb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_6113eb94-3bd9-43ca-84f3-536f6c65d35f" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_894a7ec9-6fe7-4bbe-92fe-56ccc934fdfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_37fec8fc-9f49-4f0a-a188-111e4f617c40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_6113eb94-3bd9-43ca-84f3-536f6c65d35f" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_37fec8fc-9f49-4f0a-a188-111e4f617c40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ChangeInFairMarketValueOfWarrantAndEarnOutContingentLiabilities_e45a15f8-b8a2-473e-a600-00ef4106ca50" xlink:href="wgs-20231231.xsd#wgs_ChangeInFairMarketValueOfWarrantAndEarnOutContingentLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_6113eb94-3bd9-43ca-84f3-536f6c65d35f" xlink:to="loc_wgs_ChangeInFairMarketValueOfWarrantAndEarnOutContingentLiabilities_e45a15f8-b8a2-473e-a600-00ef4106ca50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_46820dec-5424-4e83-8d3b-4e28bedb4a9f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_98f7df6f-b0ca-47eb-ae39-574c29f79a42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_46820dec-5424-4e83-8d3b-4e28bedb4a9f" xlink:to="loc_us-gaap_GrossProfit_98f7df6f-b0ca-47eb-ae39-574c29f79a42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_307551f0-ef27-4e06-996e-9da0ddf82234" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_46820dec-5424-4e83-8d3b-4e28bedb4a9f" xlink:to="loc_us-gaap_SellingAndMarketingExpense_307551f0-ef27-4e06-996e-9da0ddf82234" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_7c4a37f5-0ecb-4dc9-be96-4d8196027299" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_46820dec-5424-4e83-8d3b-4e28bedb4a9f" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_7c4a37f5-0ecb-4dc9-be96-4d8196027299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_672b9464-c97a-4206-a55f-63f405df2fb5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_46820dec-5424-4e83-8d3b-4e28bedb4a9f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_672b9464-c97a-4206-a55f-63f405df2fb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_c008acf8-4a61-4f16-89c2-9b12eab4cdb4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_46820dec-5424-4e83-8d3b-4e28bedb4a9f" xlink:to="loc_us-gaap_AssetImpairmentCharges_c008acf8-4a61-4f16-89c2-9b12eab4cdb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_5108da15-5eca-412c-8499-644399053847" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_46820dec-5424-4e83-8d3b-4e28bedb4a9f" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_5108da15-5eca-412c-8499-644399053847" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_d49279fd-dbf0-440d-a594-28ad8abf171a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_2db8321a-6c23-41ef-aaf4-a8817c57d54d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_d49279fd-dbf0-440d-a594-28ad8abf171a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_2db8321a-6c23-41ef-aaf4-a8817c57d54d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_fe42728c-f5cb-4158-8508-8b489238e7cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_d49279fd-dbf0-440d-a594-28ad8abf171a" xlink:to="loc_us-gaap_NetIncomeLoss_fe42728c-f5cb-4158-8508-8b489238e7cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_91794691-2573-45d5-a7e6-5eea54e0d6f5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_a52c1c5b-944b-4a13-9be3-925184e2681d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_91794691-2573-45d5-a7e6-5eea54e0d6f5" xlink:to="loc_us-gaap_OperatingIncomeLoss_a52c1c5b-944b-4a13-9be3-925184e2681d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_762609c7-0765-4d9c-a757-a0e97a61b1ac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_91794691-2573-45d5-a7e6-5eea54e0d6f5" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_762609c7-0765-4d9c-a757-a0e97a61b1ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6e575f6e-1cef-4fc4-8771-6e23866112d5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4a476fa3-f9fa-4034-a850-49e024b2cc87" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_6e575f6e-1cef-4fc4-8771-6e23866112d5" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_4a476fa3-f9fa-4034-a850-49e024b2cc87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_82268453-5a2c-4ec5-ac5c-c67d6fb1ab8f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_6e575f6e-1cef-4fc4-8771-6e23866112d5" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_82268453-5a2c-4ec5-ac5c-c67d6fb1ab8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_d6bc6438-6ff4-47e8-8458-09c8fbc92de1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_9a6a6d4f-6dce-43c6-a2da-d0b1f00125ea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_d6bc6438-6ff4-47e8-8458-09c8fbc92de1" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_9a6a6d4f-6dce-43c6-a2da-d0b1f00125ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_105c1c9c-63c5-407f-bf0c-039594653d0c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_d6bc6438-6ff4-47e8-8458-09c8fbc92de1" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_105c1c9c-63c5-407f-bf0c-039594653d0c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="wgs-20231231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_19ea4696-be9f-4cd2-855a-1b32adc611e2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_173769ea-e657-4bcf-ba4e-aa29b53e9995" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_19ea4696-be9f-4cd2-855a-1b32adc611e2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_173769ea-e657-4bcf-ba4e-aa29b53e9995" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3b4d96a1-33d3-4ca0-a6d0-ab68ca8b7723" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_19ea4696-be9f-4cd2-855a-1b32adc611e2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3b4d96a1-33d3-4ca0-a6d0-ab68ca8b7723" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_77314fa6-dbaa-459e-a1f5-a737e854cbb4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_19ea4696-be9f-4cd2-855a-1b32adc611e2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_77314fa6-dbaa-459e-a1f5-a737e854cbb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aebd8d46-f44b-46d3-a0d1-b5a5bd00cb82" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_d7c0fbbf-5b84-4c1e-89c0-4b95ed70e1a8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aebd8d46-f44b-46d3-a0d1-b5a5bd00cb82" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_d7c0fbbf-5b84-4c1e-89c0-4b95ed70e1a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_2ab92acf-070d-44a2-8de3-c2ded0cd85f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aebd8d46-f44b-46d3-a0d1-b5a5bd00cb82" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_2ab92acf-070d-44a2-8de3-c2ded0cd85f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarlyRepaymentOfSeniorDebt_7bfb68e9-4a9c-4034-bd3b-5be0a9f6c59e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarlyRepaymentOfSeniorDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aebd8d46-f44b-46d3-a0d1-b5a5bd00cb82" xlink:to="loc_us-gaap_EarlyRepaymentOfSeniorDebt_7bfb68e9-4a9c-4034-bd3b-5be0a9f6c59e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_5dc6cb12-bb96-4e1d-b658-796917bc6539" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aebd8d46-f44b-46d3-a0d1-b5a5bd00cb82" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_5dc6cb12-bb96-4e1d-b658-796917bc6539" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_e5c24154-8376-4142-a743-1b9f926dbecd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aebd8d46-f44b-46d3-a0d1-b5a5bd00cb82" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_e5c24154-8376-4142-a743-1b9f926dbecd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_a0e5207b-e26e-4413-abbc-92c6f79cc1a4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aebd8d46-f44b-46d3-a0d1-b5a5bd00cb82" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_a0e5207b-e26e-4413-abbc-92c6f79cc1a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_def7e404-093c-4ac7-bea0-8fc5b1f13f6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_AssetImpairmentCharges_def7e404-093c-4ac7-bea0-8fc5b1f13f6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_12ca3cac-0285-44a3-b14c-caf153ae901a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_12ca3cac-0285-44a3-b14c-caf153ae901a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_33bf7509-15e6-448f-b14c-b58d166a09e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_33bf7509-15e6-448f-b14c-b58d166a09e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_22e8aa09-fc19-41b4-8cf8-d08137d86d59" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_22e8aa09-fc19-41b4-8cf8-d08137d86d59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_e52506a3-c109-4466-96a5-11e1109b6c73" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_ShareBasedCompensation_e52506a3-c109-4466-96a5-11e1109b6c73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f530b507-f452-4b8e-b08e-eca0a6aa8a5d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_NetIncomeLoss_f530b507-f452-4b8e-b08e-eca0a6aa8a5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_26218265-5beb-427e-814e-51f0a7ad884f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_26218265-5beb-427e-814e-51f0a7ad884f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_GainLossOnDebtForgiveness_7d2571da-cd7f-431e-a8d4-01f843de822d" xlink:href="wgs-20231231.xsd#wgs_GainLossOnDebtForgiveness"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_wgs_GainLossOnDebtForgiveness_7d2571da-cd7f-431e-a8d4-01f843de822d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_94d4b9cf-20b3-4ba9-bd50-c6689bfa4215" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_94d4b9cf-20b3-4ba9-bd50-c6689bfa4215" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_16218e49-9b90-4dd1-bf1f-b3ba7298683b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_16218e49-9b90-4dd1-bf1f-b3ba7298683b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_9e1a5074-d215-4cfd-849e-c23bbf348dba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_InventoryWriteDown_9e1a5074-d215-4cfd-849e-c23bbf348dba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_1acd02eb-75d3-4226-9825-7abae0c44fa6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_1acd02eb-75d3-4226-9825-7abae0c44fa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_99e0e9f7-f793-4c3e-a177-e9c240959a1c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_99e0e9f7-f793-4c3e-a177-e9c240959a1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_f1a83164-dc9a-44f0-8eac-fd35d001b82d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_f1a83164-dc9a-44f0-8eac-fd35d001b82d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ThirdPartyPayorReserveRelease_70ef5736-55fe-4a82-a19f-7540b335036b" xlink:href="wgs-20231231.xsd#wgs_ThirdPartyPayorReserveRelease"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_bce755aa-3250-49ca-8a69-ee4f02f02100" xlink:to="loc_wgs_ThirdPartyPayorReserveRelease_70ef5736-55fe-4a82-a19f-7540b335036b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9aca2554-50df-4b7a-be51-24a0b113ce3d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4e2c6236-cce1-4dd8-a3dc-0de1d8db67bf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9aca2554-50df-4b7a-be51-24a0b113ce3d" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4e2c6236-cce1-4dd8-a3dc-0de1d8db67bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_74b2aa86-80a1-4ae5-8c87-35f262b942cb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9aca2554-50df-4b7a-be51-24a0b113ce3d" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_74b2aa86-80a1-4ae5-8c87-35f262b942cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_8aa1a2bb-3985-4751-a6b5-ecb6b7f73c8b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9aca2554-50df-4b7a-be51-24a0b113ce3d" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_8aa1a2bb-3985-4751-a6b5-ecb6b7f73c8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_1ac765dc-1992-479b-8445-29c74a5215ed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9aca2554-50df-4b7a-be51-24a0b113ce3d" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_1ac765dc-1992-479b-8445-29c74a5215ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToDevelopSoftware_d58491cc-fec4-4063-810b-55d6671a4801" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToDevelopSoftware"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9aca2554-50df-4b7a-be51-24a0b113ce3d" xlink:to="loc_us-gaap_PaymentsToDevelopSoftware_d58491cc-fec4-4063-810b-55d6671a4801" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_02f4f0fb-4aca-4c83-aa65-546b09f79bfb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9aca2554-50df-4b7a-be51-24a0b113ce3d" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_02f4f0fb-4aca-4c83-aa65-546b09f79bfb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/BusinessCombinationScheduleofRecognizedIdentifiedAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#BusinessCombinationScheduleofRecognizedIdentifiedAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/BusinessCombinationScheduleofRecognizedIdentifiedAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_cf940fb9-2096-4197-8712-27d98f926ef8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_cf940fb9-2096-4197-8712-27d98f926ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAndAccruedExpenses_02b9e07c-8491-4529-8c0d-e871f5e63cfa" xlink:href="wgs-20231231.xsd#wgs_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAndAccruedExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_wgs_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAndAccruedExpenses_02b9e07c-8491-4529-8c0d-e871f5e63cfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_6f33c021-9fe0-4026-8414-25779814ca7a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_6f33c021-9fe0-4026-8414-25779814ca7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_824b608d-b25b-47bc-b4c5-01581985621a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_824b608d-b25b-47bc-b4c5-01581985621a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_7039e116-d370-4639-aa18-2b0417fcd3a7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_7039e116-d370-4639-aa18-2b0417fcd3a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_070f3a35-a491-446d-9443-191924ec7869" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_070f3a35-a491-446d-9443-191924ec7869" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_fe19ad7d-649b-4579-9724-d09926bc1808" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_fe19ad7d-649b-4579-9724-d09926bc1808" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_33370c6a-1ec5-4804-8a34-cc660008d20b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_33370c6a-1ec5-4804-8a34-cc660008d20b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_e0dbcec5-b6e6-4de7-829f-b8f1fab47240" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_e0dbcec5-b6e6-4de7-829f-b8f1fab47240" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_8658b8cf-3093-4167-bbb4-81338fb131e9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_8658b8cf-3093-4167-bbb4-81338fb131e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_17cab048-143d-40d8-a5fc-4c693ac75376" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_17cab048-143d-40d8-a5fc-4c693ac75376" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_0a55daf3-8bf7-41d5-9cf9-f3dd7cdc7dc9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_4a62cc70-0d9d-4d83-9a23-85de35fd7879" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_0a55daf3-8bf7-41d5-9cf9-f3dd7cdc7dc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_4ffd0563-4d77-4c02-aa1f-51dc8cb93b9c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_a2d4c04f-f236-407e-88e7-f944d70a4c60" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_4ffd0563-4d77-4c02-aa1f-51dc8cb93b9c" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_a2d4c04f-f236-407e-88e7-f944d70a4c60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_2680fbb7-21ff-4392-b261-369b6f6a29b9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_4ffd0563-4d77-4c02-aa1f-51dc8cb93b9c" xlink:to="loc_us-gaap_Goodwill_2680fbb7-21ff-4392-b261-369b6f6a29b9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/FairValueMeasurementsScheduleofFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#FairValueMeasurementsScheduleofFairValueonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/FairValueMeasurementsScheduleofFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_fc83e9d5-3912-46e4-b065-860209af0a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_d55f9bd4-97e6-4b64-abc5-be9ded7d5579" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_fc83e9d5-3912-46e4-b065-860209af0a9e" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_d55f9bd4-97e6-4b64-abc5-be9ded7d5579" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_961a8983-3f64-4204-8272-f518b4cd5c2b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_fc83e9d5-3912-46e4-b065-860209af0a9e" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_961a8983-3f64-4204-8272-f518b4cd5c2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_588cfd42-1295-4caa-b212-8d2257a35419" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_457bb851-117c-41bd-adce-7843493ea251" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_588cfd42-1295-4caa-b212-8d2257a35419" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_457bb851-117c-41bd-adce-7843493ea251" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/PropertyandEquipmentComponentsDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#PropertyandEquipmentComponentsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/PropertyandEquipmentComponentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_73dab441-d8cc-47b1-823c-df476ec544b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_aa17689e-b510-4604-ae9b-4fc19ecac14c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_73dab441-d8cc-47b1-823c-df476ec544b8" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_aa17689e-b510-4604-ae9b-4fc19ecac14c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_1ddaa6e4-a4b3-46b1-a2dd-385fb321b79e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_73dab441-d8cc-47b1-823c-df476ec544b8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_1ddaa6e4-a4b3-46b1-a2dd-385fb321b79e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/GoodwillandIntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#GoodwillandIntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/GoodwillandIntangibleAssetsScheduleofAcquiredIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4c86d9aa-c689-4d81-bc69-2d285e4ab54a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_729fa602-6caa-4c5b-9138-e37ac65ac44e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4c86d9aa-c689-4d81-bc69-2d285e4ab54a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_729fa602-6caa-4c5b-9138-e37ac65ac44e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_3f378e7c-7ed4-4462-80e8-5ce7d10a8efd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4c86d9aa-c689-4d81-bc69-2d285e4ab54a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_3f378e7c-7ed4-4462-80e8-5ce7d10a8efd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/GoodwillandIntangibleAssetsScheduleofFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#GoodwillandIntangibleAssetsScheduleofFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/GoodwillandIntangibleAssetsScheduleofFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_154926d1-d8f3-4c8e-913d-bff503582198" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_c71bfbfe-08e0-4264-ac32-24f86b121ad4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_154926d1-d8f3-4c8e-913d-bff503582198" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_c71bfbfe-08e0-4264-ac32-24f86b121ad4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_9adfdf2f-fe44-4b10-8b34-ee23fa1f7366" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_154926d1-d8f3-4c8e-913d-bff503582198" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_9adfdf2f-fe44-4b10-8b34-ee23fa1f7366" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_fe5d4a73-c50a-4b3a-a50b-ce5defdcd860" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_154926d1-d8f3-4c8e-913d-bff503582198" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_fe5d4a73-c50a-4b3a-a50b-ce5defdcd860" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_2e66b034-d3ba-4df7-b6fa-ace7d54dea90" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_154926d1-d8f3-4c8e-913d-bff503582198" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_2e66b034-d3ba-4df7-b6fa-ace7d54dea90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_4ef468ef-0c8d-4a79-a7eb-149cea24afc5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_154926d1-d8f3-4c8e-913d-bff503582198" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_4ef468ef-0c8d-4a79-a7eb-149cea24afc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_cbef9e63-b7b0-49a4-b7f7-5478bf200b9d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_154926d1-d8f3-4c8e-913d-bff503582198" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_cbef9e63-b7b0-49a4-b7f7-5478bf200b9d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/RelatedPartyTransactionsRelatedPartyExpensesDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#RelatedPartyTransactionsRelatedPartyExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/RelatedPartyTransactionsRelatedPartyExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_47dce29a-1876-4843-ad94-89d15f5471f0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_7dc4294d-acd3-4055-a52b-46fc79012fbf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_47dce29a-1876-4843-ad94-89d15f5471f0" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_7dc4294d-acd3-4055-a52b-46fc79012fbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesRelatedParty_b267d40e-5e80-458f-a9e5-6cd8a5fc1108" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpensesRelatedParty"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_47dce29a-1876-4843-ad94-89d15f5471f0" xlink:to="loc_us-gaap_CostsAndExpensesRelatedParty_b267d40e-5e80-458f-a9e5-6cd8a5fc1108" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_f2cfb2b7-d3c0-4f7d-a060-ef0cb77bb848" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_47dce29a-1876-4843-ad94-89d15f5471f0" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_f2cfb2b7-d3c0-4f7d-a060-ef0cb77bb848" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/LongTermDebtMaturitiesDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#LongTermDebtMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/LongTermDebtMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_2c56ac6a-0688-4081-8d0d-137970e65e45" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_6b3a0da1-c5cf-41e5-8b0b-545ffe71da13" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2c56ac6a-0688-4081-8d0d-137970e65e45" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_6b3a0da1-c5cf-41e5-8b0b-545ffe71da13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_6c5679f5-1d24-4f49-8c70-8992403447df" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2c56ac6a-0688-4081-8d0d-137970e65e45" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_6c5679f5-1d24-4f49-8c70-8992403447df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_a07d6636-7968-4915-a9cb-f75c13c1d35f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2c56ac6a-0688-4081-8d0d-137970e65e45" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_a07d6636-7968-4915-a9cb-f75c13c1d35f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_d909de1d-a103-4089-97b2-a0d3cf24cb1b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2c56ac6a-0688-4081-8d0d-137970e65e45" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_d909de1d-a103-4089-97b2-a0d3cf24cb1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_50a82b7c-b8fb-4008-b155-c2d0448edd46" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2c56ac6a-0688-4081-8d0d-137970e65e45" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_50a82b7c-b8fb-4008-b155-c2d0448edd46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_9a71e79a-82a4-47cb-a93a-81a919b6a1d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2c56ac6a-0688-4081-8d0d-137970e65e45" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_9a71e79a-82a4-47cb-a93a-81a919b6a1d9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/LeasesScheduleofAssetsandLiabilitiesLesseeDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#LeasesScheduleofAssetsandLiabilitiesLesseeDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/LeasesScheduleofAssetsandLiabilitiesLesseeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseAssets_0f99c3a8-2832-48d3-98af-71e4ba4d8029" xlink:href="wgs-20231231.xsd#wgs_LeaseAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_253cfdb4-ad35-49e0-8ef8-2cb9256bce8e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseAssets_0f99c3a8-2832-48d3-98af-71e4ba4d8029" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_253cfdb4-ad35-49e0-8ef8-2cb9256bce8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_2e703d1b-e10d-406f-88ab-d07a95fcd361" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseAssets_0f99c3a8-2832-48d3-98af-71e4ba4d8029" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_2e703d1b-e10d-406f-88ab-d07a95fcd361" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseLiabilities_6663b1a6-5d85-4cd0-8cb2-7ae44a2deddb" xlink:href="wgs-20231231.xsd#wgs_LeaseLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_b0333c7b-7bca-479b-93ad-1a1934eda003" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseLiabilities_6663b1a6-5d85-4cd0-8cb2-7ae44a2deddb" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_b0333c7b-7bca-479b-93ad-1a1934eda003" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_9ad54ff2-7c7a-404e-95d2-2557a16adc3d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseLiabilities_6663b1a6-5d85-4cd0-8cb2-7ae44a2deddb" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_9ad54ff2-7c7a-404e-95d2-2557a16adc3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_bcdefe86-5faf-4685-a6f1-9df98a82640c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseLiabilities_6663b1a6-5d85-4cd0-8cb2-7ae44a2deddb" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_bcdefe86-5faf-4685-a6f1-9df98a82640c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_db65181a-1ab4-48e0-84e7-63b33ae2eac8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseLiabilities_6663b1a6-5d85-4cd0-8cb2-7ae44a2deddb" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_db65181a-1ab4-48e0-84e7-63b33ae2eac8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/LeasesScheduleofLeaseCostDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#LeasesScheduleofLeaseCostDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/LeasesScheduleofLeaseCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_04d9c4be-46f4-4b59-911c-65dae43a6539" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_FinanceLeaseCost_20e1b83c-fecb-41a0-9437-65df19d2ea86" xlink:href="wgs-20231231.xsd#wgs_FinanceLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_04d9c4be-46f4-4b59-911c-65dae43a6539" xlink:to="loc_wgs_FinanceLeaseCost_20e1b83c-fecb-41a0-9437-65df19d2ea86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseCostExcludingFinanceLeaseCosts_bbe48da2-99ad-4cec-8625-abca204baae8" xlink:href="wgs-20231231.xsd#wgs_LeaseCostExcludingFinanceLeaseCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_04d9c4be-46f4-4b59-911c-65dae43a6539" xlink:to="loc_wgs_LeaseCostExcludingFinanceLeaseCosts_bbe48da2-99ad-4cec-8625-abca204baae8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_FinanceLeaseCost_c2b43bd5-72a4-4929-9dfd-2177a2ee2275" xlink:href="wgs-20231231.xsd#wgs_FinanceLeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_112bf602-8aea-4829-a478-c73db75e605d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_FinanceLeaseCost_c2b43bd5-72a4-4929-9dfd-2177a2ee2275" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_112bf602-8aea-4829-a478-c73db75e605d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_08b3703e-b281-44c2-b423-5b2a2c1893aa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_FinanceLeaseCost_c2b43bd5-72a4-4929-9dfd-2177a2ee2275" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_08b3703e-b281-44c2-b423-5b2a2c1893aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LeaseCostExcludingFinanceLeaseCosts_ef1aa171-20f3-4fea-86ac-5a5ec7a59e38" xlink:href="wgs-20231231.xsd#wgs_LeaseCostExcludingFinanceLeaseCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_2cf6070b-c0fa-4e6c-86ae-418c813fd312" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseCostExcludingFinanceLeaseCosts_ef1aa171-20f3-4fea-86ac-5a5ec7a59e38" xlink:to="loc_us-gaap_ShortTermLeaseCost_2cf6070b-c0fa-4e6c-86ae-418c813fd312" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_e4fca9e3-229b-48fb-abad-a4bb9c33978a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseCostExcludingFinanceLeaseCosts_ef1aa171-20f3-4fea-86ac-5a5ec7a59e38" xlink:to="loc_us-gaap_OperatingLeaseCost_e4fca9e3-229b-48fb-abad-a4bb9c33978a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_0d3d7990-bb6e-47f2-9278-d694fe1943fd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LeaseCostExcludingFinanceLeaseCosts_ef1aa171-20f3-4fea-86ac-5a5ec7a59e38" xlink:to="loc_us-gaap_VariableLeaseCost_0d3d7990-bb6e-47f2-9278-d694fe1943fd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/LeasesScheduleofFutureMinimumRentalPaymentsforLeasesDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#LeasesScheduleofFutureMinimumRentalPaymentsforLeasesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/LeasesScheduleofFutureMinimumRentalPaymentsforLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityUndiscountedExcessAmount_12d3b957-41b0-420c-a745-06f86254b0ee" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityUndiscountedExcessAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_0fc0642a-8534-4130-a7c3-be213b26e803" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityUndiscountedExcessAmount_12d3b957-41b0-420c-a745-06f86254b0ee" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_0fc0642a-8534-4130-a7c3-be213b26e803" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_26663533-e112-420c-b015-7840a2b449b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityUndiscountedExcessAmount_12d3b957-41b0-420c-a745-06f86254b0ee" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_26663533-e112-420c-b015-7840a2b449b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52cf4cf4-1ed6-431a-bb8f-c4731393892f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_8395d8ad-0953-4e8f-bb69-89531fe4e1cd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52cf4cf4-1ed6-431a-bb8f-c4731393892f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_8395d8ad-0953-4e8f-bb69-89531fe4e1cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_9d38a3c2-29bc-440b-8ee5-7c154ec53ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52cf4cf4-1ed6-431a-bb8f-c4731393892f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_9d38a3c2-29bc-440b-8ee5-7c154ec53ce0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_d5b02df8-3964-421b-9feb-9646301ae447" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52cf4cf4-1ed6-431a-bb8f-c4731393892f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_d5b02df8-3964-421b-9feb-9646301ae447" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_8d3bd531-1d6d-4535-aaf1-dad6f684a92d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52cf4cf4-1ed6-431a-bb8f-c4731393892f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_8d3bd531-1d6d-4535-aaf1-dad6f684a92d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_419d8245-62ad-4288-9d0a-f3df46e6f33e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52cf4cf4-1ed6-431a-bb8f-c4731393892f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_419d8245-62ad-4288-9d0a-f3df46e6f33e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_db457f7a-bcf3-4750-bcb4-08067121fd20" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52cf4cf4-1ed6-431a-bb8f-c4731393892f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_db457f7a-bcf3-4750-bcb4-08067121fd20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive_d469f4a8-d314-48f7-a939-97dbbf4f805a" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_fe77ba2d-6758-495c-acc3-87b69d32ea62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive_d469f4a8-d314-48f7-a939-97dbbf4f805a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_fe77ba2d-6758-495c-acc3-87b69d32ea62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_3c00e85e-0f4b-4c12-929e-c32af43614bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive_d469f4a8-d314-48f7-a939-97dbbf4f805a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_3c00e85e-0f4b-4c12-929e-c32af43614bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_460880e7-01cd-4b57-b274-1718cf162b89" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_fc8c29d9-445b-4153-9faa-8cd45d5c5d6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_460880e7-01cd-4b57-b274-1718cf162b89" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_fc8c29d9-445b-4153-9faa-8cd45d5c5d6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d7c77060-6273-419d-896a-15fe26722749" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_460880e7-01cd-4b57-b274-1718cf162b89" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d7c77060-6273-419d-896a-15fe26722749" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_043209f7-708d-4a62-9412-22b8cd2e3f1d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_254458fe-a384-425c-ae4a-fb205c8891aa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_043209f7-708d-4a62-9412-22b8cd2e3f1d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_254458fe-a384-425c-ae4a-fb205c8891aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_cbc4e14e-1e45-4434-9232-813985b5e8eb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_043209f7-708d-4a62-9412-22b8cd2e3f1d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_cbc4e14e-1e45-4434-9232-813985b5e8eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_5cf787eb-1554-4b09-af3c-53b062a28551" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_043209f7-708d-4a62-9412-22b8cd2e3f1d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_5cf787eb-1554-4b09-af3c-53b062a28551" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_95807264-3e52-4086-b1db-cfae6666fae2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_043209f7-708d-4a62-9412-22b8cd2e3f1d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_95807264-3e52-4086-b1db-cfae6666fae2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_20b906db-f4cc-41bc-97c1-a611e5dacdea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_043209f7-708d-4a62-9412-22b8cd2e3f1d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_20b906db-f4cc-41bc-97c1-a611e5dacdea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_8b21a435-e12d-47c7-a5f2-49b3224d3a5f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_043209f7-708d-4a62-9412-22b8cd2e3f1d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_8b21a435-e12d-47c7-a5f2-49b3224d3a5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths_292aa00e-21fe-44aa-9b57-a01fcbc48434" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_6f1a2f42-377e-47e1-9e04-dda64c992d0a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths_292aa00e-21fe-44aa-9b57-a01fcbc48434" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_6f1a2f42-377e-47e1-9e04-dda64c992d0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_921251cf-0a4c-4a09-8606-636ca74e9227" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths_292aa00e-21fe-44aa-9b57-a01fcbc48434" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_921251cf-0a4c-4a09-8606-636ca74e9227" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree_00efd75d-015c-42a7-8127-bf80fd72a275" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_a0331c1f-9b4d-4e30-82dd-f30f2fd22497" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree_00efd75d-015c-42a7-8127-bf80fd72a275" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_a0331c1f-9b4d-4e30-82dd-f30f2fd22497" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_8f70ce5c-af4d-49ea-94ac-09dba18425d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree_00efd75d-015c-42a7-8127-bf80fd72a275" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_8f70ce5c-af4d-49ea-94ac-09dba18425d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive_b124ff7a-4a07-417b-b1f3-4e070c5a85ab" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_d0c24e95-80f1-46cd-8da9-1fe7a89e8581" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive_b124ff7a-4a07-417b-b1f3-4e070c5a85ab" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_d0c24e95-80f1-46cd-8da9-1fe7a89e8581" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_6a1aa3ff-1e8c-4b1e-bad0-6a712078b325" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive_b124ff7a-4a07-417b-b1f3-4e070c5a85ab" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_6a1aa3ff-1e8c-4b1e-bad0-6a712078b325" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo_10b2d1fe-f732-4147-ac4d-bf402d880ff1" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_86441d8a-d0ea-4df4-a190-258abc5d587f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo_10b2d1fe-f732-4147-ac4d-bf402d880ff1" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_86441d8a-d0ea-4df4-a190-258abc5d587f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_46a1fd4b-11bc-4783-9d11-ea4556457715" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo_10b2d1fe-f732-4147-ac4d-bf402d880ff1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_46a1fd4b-11bc-4783-9d11-ea4556457715" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour_c6a71a89-07d2-45d9-bbad-4ae4c41f6f16" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_57a829c2-5ef0-42ec-8f07-543abcbeddf9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour_c6a71a89-07d2-45d9-bbad-4ae4c41f6f16" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_57a829c2-5ef0-42ec-8f07-543abcbeddf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_e004f4b6-9562-405c-85e3-b8cdacfa41a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour_c6a71a89-07d2-45d9-bbad-4ae4c41f6f16" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_e004f4b6-9562-405c-85e3-b8cdacfa41a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiability_9a77b5c8-485f-4b2f-8d2d-159158505e2d" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_db59014e-7880-4911-abb8-8532588e951e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiability_9a77b5c8-485f-4b2f-8d2d-159158505e2d" xlink:to="loc_us-gaap_FinanceLeaseLiability_db59014e-7880-4911-abb8-8532588e951e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_5063f647-4e97-42b5-90a2-1b51113c863e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiability_9a77b5c8-485f-4b2f-8d2d-159158505e2d" xlink:to="loc_us-gaap_OperatingLeaseLiability_5063f647-4e97-42b5-90a2-1b51113c863e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/LeasesScheduleofFutureMinimumRentalPaymentsforLeasesDetails_1" xlink:type="simple" xlink:href="wgs-20231231.xsd#LeasesScheduleofFutureMinimumRentalPaymentsforLeasesDetails_1"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/LeasesScheduleofFutureMinimumRentalPaymentsforLeasesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_39987836-13ea-42a0-bf85-d6bfd8ac7699" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo_a7a34940-efe5-4738-baad-d9bd5b8a2044" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_39987836-13ea-42a0-bf85-d6bfd8ac7699" xlink:to="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearTwo_a7a34940-efe5-4738-baad-d9bd5b8a2044" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour_a91ac138-2879-40b2-8f3c-4aa7fbea906d" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_39987836-13ea-42a0-bf85-d6bfd8ac7699" xlink:to="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFour_a91ac138-2879-40b2-8f3c-4aa7fbea906d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive_da415184-53fa-4728-9132-8e66e9f04a4f" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_39987836-13ea-42a0-bf85-d6bfd8ac7699" xlink:to="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearFive_da415184-53fa-4728-9132-8e66e9f04a4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree_bfa03cbe-9f16-4743-b209-8e9f2fc13bff" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_39987836-13ea-42a0-bf85-d6bfd8ac7699" xlink:to="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueYearThree_bfa03cbe-9f16-4743-b209-8e9f2fc13bff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths_c94c181e-e310-4fb0-b86a-673d6209acd2" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_39987836-13ea-42a0-bf85-d6bfd8ac7699" xlink:to="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueNextTwelveMonths_c94c181e-e310-4fb0-b86a-673d6209acd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive_202b32e7-490f-4794-bc5b-b79809745978" xlink:href="wgs-20231231.xsd#wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDue_39987836-13ea-42a0-bf85-d6bfd8ac7699" xlink:to="loc_wgs_LesseeOperatingAndFinanceAndLiabilityPaymentsDueAfterYearFive_202b32e7-490f-4794-bc5b-b79809745978" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/PurchaseCommitmentsandContingenciesScheduleofMaterialPurchaseCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligation_20069257-1d6e-4aa4-8a33-9e253091b975" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_86f513d9-7b15-4bfe-9695-4d64184d616f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligationDueInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_20069257-1d6e-4aa4-8a33-9e253091b975" xlink:to="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_86f513d9-7b15-4bfe-9695-4d64184d616f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInSecondYear_7780e194-abbc-481d-b654-abb1b43c14bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PurchaseObligationDueInSecondYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_20069257-1d6e-4aa4-8a33-9e253091b975" xlink:to="loc_us-gaap_PurchaseObligationDueInSecondYear_7780e194-abbc-481d-b654-abb1b43c14bd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/IncomeTaxesScheduleofIncomeTaxProvisionDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#IncomeTaxesScheduleofIncomeTaxProvisionDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/IncomeTaxesScheduleofIncomeTaxProvisionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_2d8c3f4c-ad20-4ae0-901d-ecd069f5c96c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_3fb0aff3-15cf-43df-b656-50c009f4835c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_2d8c3f4c-ad20-4ae0-901d-ecd069f5c96c" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_3fb0aff3-15cf-43df-b656-50c009f4835c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_7531bc73-76d3-4c5d-a7c5-5ec60bf564da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_2d8c3f4c-ad20-4ae0-901d-ecd069f5c96c" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_7531bc73-76d3-4c5d-a7c5-5ec60bf564da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_55cd4b8c-0114-4c1f-b1e7-e4e3c810a7d1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_2d8c3f4c-ad20-4ae0-901d-ecd069f5c96c" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_55cd4b8c-0114-4c1f-b1e7-e4e3c810a7d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_06d28404-76a0-45a8-aa37-01f95faa7b62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_104d5c2c-66a1-4739-afd6-3bfcb6527e89" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_06d28404-76a0-45a8-aa37-01f95faa7b62" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_104d5c2c-66a1-4739-afd6-3bfcb6527e89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_04d0c6d4-2bc3-4183-9b83-722971d98227" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_06d28404-76a0-45a8-aa37-01f95faa7b62" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_04d0c6d4-2bc3-4183-9b83-722971d98227" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_d689eb99-6756-4b57-bf04-7985092eca4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_b9a67a12-f311-438b-b834-17fb7c6c5dac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_d689eb99-6756-4b57-bf04-7985092eca4f" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_b9a67a12-f311-438b-b834-17fb7c6c5dac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_15f93ce0-a8af-4fc8-90d5-946f7d6da184" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_d689eb99-6756-4b57-bf04-7985092eca4f" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_15f93ce0-a8af-4fc8-90d5-946f7d6da184" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_36653cbb-f88f-4ce6-a5fe-bdf79d85ea04" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_d689eb99-6756-4b57-bf04-7985092eca4f" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_36653cbb-f88f-4ce6-a5fe-bdf79d85ea04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_862a7e48-3038-423d-a18c-3040afc66a28" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_9bcc9f34-76c4-414e-b0f9-d4695ed58d3c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_862a7e48-3038-423d-a18c-3040afc66a28" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_9bcc9f34-76c4-414e-b0f9-d4695ed58d3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_428484b6-4c8a-45a1-822b-e8670cce3997" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_862a7e48-3038-423d-a18c-3040afc66a28" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_428484b6-4c8a-45a1-822b-e8670cce3997" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/IncomeTaxesReconciliationofEffectiveTaxRateDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#IncomeTaxesReconciliationofEffectiveTaxRateDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/IncomeTaxesReconciliationofEffectiveTaxRateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_4892c51a-f712-4adf-ba5e-999d32cf2346" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_4892c51a-f712-4adf-ba5e-999d32cf2346" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses_950a9c40-1971-4fc0-90ff-ba41d6a83b95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseImpairmentLosses_950a9c40-1971-4fc0-90ff-ba41d6a83b95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_7c90b6be-f411-4db4-b71e-c19b629d85c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_7c90b6be-f411-4db4-b71e-c19b629d85c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_8093391a-2026-439e-899b-1af59eddffed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_8093391a-2026-439e-899b-1af59eddffed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_c1f9a282-f8ec-40f7-bcae-0ddef60eac8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_c1f9a282-f8ec-40f7-bcae-0ddef60eac8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_7520b551-d8ed-4f74-98a4-3cf506ea4a4e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_7520b551-d8ed-4f74-98a4-3cf506ea4a4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_24160ced-d6ab-45f8-ac88-cc51c6d68189" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_24160ced-d6ab-45f8-ac88-cc51c6d68189" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_EffectiveIncomeTaxRateReconciliationUnrealizedFairMarketValueGainOnWarrants_3d2da910-4f65-495a-912e-2000430a4015" xlink:href="wgs-20231231.xsd#wgs_EffectiveIncomeTaxRateReconciliationUnrealizedFairMarketValueGainOnWarrants"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_wgs_EffectiveIncomeTaxRateReconciliationUnrealizedFairMarketValueGainOnWarrants_3d2da910-4f65-495a-912e-2000430a4015" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_cb04b730-36cf-4132-95eb-ac9d89ad96c8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_cb04b730-36cf-4132-95eb-ac9d89ad96c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_EffectiveIncomeTaxRateReconciliationNondeductibleExpensePayForCoveredEmployeesLimitationPercent_0d905c00-0eec-4677-880f-33c9ce9dcdd2" xlink:href="wgs-20231231.xsd#wgs_EffectiveIncomeTaxRateReconciliationNondeductibleExpensePayForCoveredEmployeesLimitationPercent"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b7c21d03-d93e-4f5c-b9db-778f60df8d98" xlink:to="loc_wgs_EffectiveIncomeTaxRateReconciliationNondeductibleExpensePayForCoveredEmployeesLimitationPercent_0d905c00-0eec-4677-880f-33c9ce9dcdd2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/IncomeTaxesNetDeferredTaxAssetsDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#IncomeTaxesNetDeferredTaxAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/IncomeTaxesNetDeferredTaxAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_3729e07c-ddd6-49e8-b056-04384efc1989" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_4ec7c89d-58a4-4a8f-bf1e-8cc88a2672b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_3729e07c-ddd6-49e8-b056-04384efc1989" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_4ec7c89d-58a4-4a8f-bf1e-8cc88a2672b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_5b039492-8432-47ea-b442-aa855385317e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_3729e07c-ddd6-49e8-b056-04384efc1989" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_5b039492-8432-47ea-b442-aa855385317e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilities_0f99b523-42ea-4e16-b1c7-afe74392b4fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_7bbc5c7a-f56e-4380-864d-3435b80512ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_0f99b523-42ea-4e16-b1c7-afe74392b4fb" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_7bbc5c7a-f56e-4380-864d-3435b80512ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_9ce99ca3-0f94-4696-8266-a746d1098fec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_0f99b523-42ea-4e16-b1c7-afe74392b4fb" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_9ce99ca3-0f94-4696-8266-a746d1098fec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_DeferredTaxAssetsDeferredExpenseCapitalizedSoftware_a9977e2b-7c28-4c81-bc73-fd29490d0bc4" xlink:href="wgs-20231231.xsd#wgs_DeferredTaxAssetsDeferredExpenseCapitalizedSoftware"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_wgs_DeferredTaxAssetsDeferredExpenseCapitalizedSoftware_a9977e2b-7c28-4c81-bc73-fd29490d0bc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_e3b161b6-c588-4166-83d1-ba6608b7e123" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_e3b161b6-c588-4166-83d1-ba6608b7e123" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_DeferredTaxAssetsThirdPartyLiability_7b37028b-7fd5-4c77-81d2-93465a30e69d" xlink:href="wgs-20231231.xsd#wgs_DeferredTaxAssetsThirdPartyLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_wgs_DeferredTaxAssetsThirdPartyLiability_7b37028b-7fd5-4c77-81d2-93465a30e69d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_cd4fc26b-6143-4426-869b-f9bc950fc1d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_cd4fc26b-6143-4426-869b-f9bc950fc1d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_94e14616-81f7-40d3-833e-7aa704a9257c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_94e14616-81f7-40d3-833e-7aa704a9257c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInventory_e1415584-8f73-4a4c-9968-0ce6de4af3be" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsInventory"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsInventory_e1415584-8f73-4a4c-9968-0ce6de4af3be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_a7dfaedd-e9c5-45c0-8bb9-3ab8c2379e7c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_a7dfaedd-e9c5-45c0-8bb9-3ab8c2379e7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_31e58b6d-c8fe-49d8-8394-44228633a554" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_31e58b6d-c8fe-49d8-8394-44228633a554" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_86a8c73a-c5be-4a2e-94d1-138932027535" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_86a8c73a-c5be-4a2e-94d1-138932027535" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_c97e51bc-2669-4e24-9b15-d1cf83f18130" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_c97e51bc-2669-4e24-9b15-d1cf83f18130" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_DeferredTaxAssetsResearchAndDevelopmentAmortization_9b6e14e7-58ef-42a3-b2a2-59ecb8ea511b" xlink:href="wgs-20231231.xsd#wgs_DeferredTaxAssetsResearchAndDevelopmentAmortization"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_wgs_DeferredTaxAssetsResearchAndDevelopmentAmortization_9b6e14e7-58ef-42a3-b2a2-59ecb8ea511b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent_26e64226-c7b9-4e8d-8c1b-15c428587ae9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_a44c40d4-7eef-4942-82b4-7e1dd03141a0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent_26e64226-c7b9-4e8d-8c1b-15c428587ae9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_9bdbc165-d857-486e-904e-279159cca545" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOtherFiniteLivedAssets_928128b9-6411-469c-8e65-33cade2cb511" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilitiesOtherFiniteLivedAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_9bdbc165-d857-486e-904e-279159cca545" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOtherFiniteLivedAssets_928128b9-6411-469c-8e65-33cade2cb511" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_3fe5a264-a5fe-4c8c-a3a8-79eda297b2c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_9bdbc165-d857-486e-904e-279159cca545" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_3fe5a264-a5fe-4c8c-a3a8-79eda297b2c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_7d4a64e1-c7f8-4cb8-95b9-e035676b4622" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_9bdbc165-d857-486e-904e-279159cca545" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_7d4a64e1-c7f8-4cb8-95b9-e035676b4622" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_efbc00a5-c39e-422c-bc0d-a6f9712fd52b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_9bdbc165-d857-486e-904e-279159cca545" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_efbc00a5-c39e-422c-bc0d-a6f9712fd52b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationCashCashEquivalentsAndRestrictedCashDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#SupplementalFinancialInformationCashCashEquivalentsAndRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationCashCashEquivalentsAndRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_168b6bbc-4fe5-45f1-b120-c55d828fef0c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_95b0c36c-54cd-4e20-87d7-c1fd79dbba8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_168b6bbc-4fe5-45f1-b120-c55d828fef0c" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_95b0c36c-54cd-4e20-87d7-c1fd79dbba8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_9a33bcb2-6f0e-43de-8213-19cb40ac00da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_168b6bbc-4fe5-45f1-b120-c55d828fef0c" xlink:to="loc_us-gaap_RestrictedCash_9a33bcb2-6f0e-43de-8213-19cb40ac00da" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationAccruedExpensesDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#SupplementalFinancialInformationAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_240b8cd3-63db-48f3-a661-6f1af9b46e2f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_d165a9ed-d99e-4466-beda-8c451827f1b4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_240b8cd3-63db-48f3-a661-6f1af9b46e2f" xlink:to="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_d165a9ed-d99e-4466-beda-8c451827f1b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_8c5fd3dd-2eb1-44ee-8bcc-5da9b87eaa85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_240b8cd3-63db-48f3-a661-6f1af9b46e2f" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_8c5fd3dd-2eb1-44ee-8bcc-5da9b87eaa85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_d476d075-aa5c-42d1-adba-0f34a3601e61" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_240b8cd3-63db-48f3-a661-6f1af9b46e2f" xlink:to="loc_us-gaap_AccountsPayableCurrent_d476d075-aa5c-42d1-adba-0f34a3601e61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedInsuranceCurrent_525872f1-f14a-4897-9393-41542f9d20ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedInsuranceCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_240b8cd3-63db-48f3-a661-6f1af9b46e2f" xlink:to="loc_us-gaap_AccruedInsuranceCurrent_525872f1-f14a-4897-9393-41542f9d20ec" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#SupplementalFinancialInformationOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_b5b0b0c0-d9dd-4bdc-9aa8-06440af3bb01" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_b5b0b0c0-d9dd-4bdc-9aa8-06440af3bb01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_a92fb6b9-1d2c-44c9-ad14-f43e3144730d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_AccruedBonusesCurrent_a92fb6b9-1d2c-44c9-ad14-f43e3144730d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalesCommissionCurrent_bea31228-25a5-498a-a0fd-f47c0093bba9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedSalesCommissionCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_AccruedSalesCommissionCurrent_bea31228-25a5-498a-a0fd-f47c0093bba9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalariesCurrent_097460d5-17d0-4dbc-9c3d-4e59918abf14" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedSalariesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_AccruedSalariesCurrent_097460d5-17d0-4dbc-9c3d-4e59918abf14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_IndemnificationLiabilitiesCurrent_f19e7951-c9b2-4ac6-a7a6-a28b984cd68e" xlink:href="wgs-20231231.xsd#wgs_IndemnificationLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_wgs_IndemnificationLiabilitiesCurrent_f19e7951-c9b2-4ac6-a7a6-a28b984cd68e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AccruedSeveranceCurrent_9154e202-01de-4b3a-be9c-688fc25b3cd9" xlink:href="wgs-20231231.xsd#wgs_AccruedSeveranceCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_wgs_AccruedSeveranceCurrent_9154e202-01de-4b3a-be9c-688fc25b3cd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesCurrent_fb69a03a-5981-463d-83fe-c005a8d7afe8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherSundryLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_OtherSundryLiabilitiesCurrent_fb69a03a-5981-463d-83fe-c005a8d7afe8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsCurrentGross_b8be0fb1-8fb9-4608-be69-64d9a5b413cc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredFinanceCostsCurrentGross"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_DeferredFinanceCostsCurrentGross_b8be0fb1-8fb9-4608-be69-64d9a5b413cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_16667787-9319-41b2-b249-8061df0569b0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedEmployeeBenefitsCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_AccruedEmployeeBenefitsCurrent_16667787-9319-41b2-b249-8061df0569b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_c4844d58-35d3-416e-834a-1736edcefc2c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_25c0e430-7ccd-42a5-81da-95a4b93b9ae6" xlink:to="loc_us-gaap_LongTermDebtCurrent_c4844d58-35d3-416e-834a-1736edcefc2c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SupplementalFinancialInformationOtherLiabilitiesDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#SupplementalFinancialInformationOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SupplementalFinancialInformationOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_aa2e6306-d969-4b68-a996-21329a35bd18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_5a4dccfd-0973-42c3-9256-e916c7778b51" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_aa2e6306-d969-4b68-a996-21329a35bd18" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_5a4dccfd-0973-42c3-9256-e916c7778b51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_ThirdPartyPayorReserveNonCurrent_8d6532f6-0544-4b12-b7bc-582002916797" xlink:href="wgs-20231231.xsd#wgs_ThirdPartyPayorReserveNonCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_aa2e6306-d969-4b68-a996-21329a35bd18" xlink:to="loc_wgs_ThirdPartyPayorReserveNonCurrent_8d6532f6-0544-4b12-b7bc-582002916797" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_WarrantLiability_3b91176e-0fff-457e-9dce-f15a7f98c782" xlink:href="wgs-20231231.xsd#wgs_WarrantLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_aa2e6306-d969-4b68-a996-21329a35bd18" xlink:to="loc_wgs_WarrantLiability_3b91176e-0fff-457e-9dce-f15a7f98c782" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.genedx.com/role/SegmentReportingScheduleofSegmentReportingInformationDetails" xlink:type="simple" xlink:href="wgs-20231231.xsd#SegmentReportingScheduleofSegmentReportingInformationDetails"/>
  <link:calculationLink xlink:role="http://www.genedx.com/role/SegmentReportingScheduleofSegmentReportingInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedGrossMargin_34bf946e-222e-4842-ad52-d0b2cdb2ed13" xlink:href="wgs-20231231.xsd#wgs_AdjustedGrossMargin"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedCostOfGoodSold_bc87e825-e04e-4ab9-8572-35b6d699a027" xlink:href="wgs-20231231.xsd#wgs_AdjustedCostOfGoodSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_AdjustedGrossMargin_34bf946e-222e-4842-ad52-d0b2cdb2ed13" xlink:to="loc_wgs_AdjustedCostOfGoodSold_bc87e825-e04e-4ab9-8572-35b6d699a027" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9aa0107f-a061-4f4a-a27b-434553374d78" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_wgs_AdjustedGrossMargin_34bf946e-222e-4842-ad52-d0b2cdb2ed13" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9aa0107f-a061-4f4a-a27b-434553374d78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_fabeb7de-677a-4d66-9a61-531cc4b1a822" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_74e31761-7683-479a-8df9-9ede26657bd7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_fabeb7de-677a-4d66-9a61-531cc4b1a822" xlink:to="loc_us-gaap_RestructuringCharges_74e31761-7683-479a-8df9-9ede26657bd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_571b5caf-113e-4119-8a43-46ccecebd2f1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_fabeb7de-677a-4d66-9a61-531cc4b1a822" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_571b5caf-113e-4119-8a43-46ccecebd2f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_wgs_AdjustedGrossMargin_83eef8c2-2b8e-4c14-9425-e3f9317f901f" xlink:href="wgs-20231231.xsd#wgs_AdjustedGrossMargin"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_fabeb7de-677a-4d66-9a61-531cc4b1a822" xlink:to="loc_wgs_AdjustedGrossMargin_83eef8c2-2b8e-4c14-9425-e3f9317f901f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_6b9fadfc-96f7-4eaf-b04f-85ca70edcf64" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_fabeb7de-677a-4d66-9a61-531cc4b1a822" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_6b9fadfc-96f7-4eaf-b04f-85ca70edcf64" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
