<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c952a-b307-77ac-97e7-e44d339e205a,g:2be4d70a-65f7-4b13-8e18-b244282a9b23-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="wgs-20260227.xsd#DocumentandEntityInformationDocument"/>
  <link:definitionLink xlink:role="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_019c952a-b307-7329-99bf-a347b271830e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntitiesTable_019c952a-b307-7329-99bf-a347b271830e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019c952a-b307-7aa6-a525-9389c0e2eed9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_019c952a-b307-7329-99bf-a347b271830e" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019c952a-b307-7aa6-a525-9389c0e2eed9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c952a-b307-7aa6-a525-9389c0e2eed9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c952a-b307-7aa6-a525-9389c0e2eed9" xlink:to="loc_us-gaap_ClassOfStockDomain_019c952a-b307-7aa6-a525-9389c0e2eed9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c952a-b307-7c34-859d-b66b606d79d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c952a-b307-7aa6-a525-9389c0e2eed9" xlink:to="loc_us-gaap_ClassOfStockDomain_019c952a-b307-7c34-859d-b66b606d79d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019c952a-b307-7eaa-a862-90f8283b62f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c952a-b307-7c34-859d-b66b606d79d4" xlink:to="loc_us-gaap_CommonClassAMember_019c952a-b307-7eaa-a862-90f8283b62f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019c952a-b307-79cd-986d-d1018413c640" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c952a-b307-7c34-859d-b66b606d79d4" xlink:to="loc_us-gaap_WarrantMember_019c952a-b307-79cd-986d-d1018413c640" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019c952a-b307-7948-b50a-56643cef87f1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_DocumentType_019c952a-b307-7948-b50a-56643cef87f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019c952a-b307-78ca-9da8-e64ce9840b88" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_DocumentPeriodEndDate_019c952a-b307-78ca-9da8-e64ce9840b88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019c952a-b307-759e-bdfa-003f0a8e8a0c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityRegistrantName_019c952a-b307-759e-bdfa-003f0a8e8a0c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019c952a-b307-7b0e-ba91-e1e73a1c214c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019c952a-b307-7b0e-ba91-e1e73a1c214c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019c952a-b307-7360-928b-a7d76caf8d71" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityFileNumber_019c952a-b307-7360-928b-a7d76caf8d71" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019c952a-b307-78a9-a93e-5ece0be3d651" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityTaxIdentificationNumber_019c952a-b307-78a9-a93e-5ece0be3d651" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019c952a-b307-79c8-9d7c-601f500259e0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityAddressAddressLine1_019c952a-b307-79c8-9d7c-601f500259e0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019c952a-b307-73b7-a5d0-2cdf0cb7debb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityAddressCityOrTown_019c952a-b307-73b7-a5d0-2cdf0cb7debb" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019c952a-b307-708d-bb1a-b2dfe84d7eed" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityAddressStateOrProvince_019c952a-b307-708d-bb1a-b2dfe84d7eed" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019c952a-b307-7324-bed8-d78ad6fb693d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityAddressPostalZipCode_019c952a-b307-7324-bed8-d78ad6fb693d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019c952a-b307-7451-af5d-427e94a071c9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_CityAreaCode_019c952a-b307-7451-af5d-427e94a071c9" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019c952a-b307-7f46-8252-71fcc06ae9d7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_LocalPhoneNumber_019c952a-b307-7f46-8252-71fcc06ae9d7" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019c952a-b307-78ae-aaca-2c59528b6dc0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_WrittenCommunications_019c952a-b307-78ae-aaca-2c59528b6dc0" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019c952a-b307-7930-be13-ae0ab9d2ff97" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_SolicitingMaterial_019c952a-b307-7930-be13-ae0ab9d2ff97" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019c952a-b307-7d01-92da-39476c661e21" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_PreCommencementTenderOffer_019c952a-b307-7d01-92da-39476c661e21" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019c952a-b307-77fc-81b4-d3387854f1de" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019c952a-b307-77fc-81b4-d3387854f1de" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019c952a-b307-7559-9999-548e3a9bba4d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_Security12bTitle_019c952a-b307-7559-9999-548e3a9bba4d" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019c952a-b307-722a-9109-d1799c95f6bd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_TradingSymbol_019c952a-b307-722a-9109-d1799c95f6bd" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019c952a-b307-7e46-b3f1-73297bf474aa" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_SecurityExchangeName_019c952a-b307-7e46-b3f1-73297bf474aa" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019c952a-b307-7f64-aef6-96b92a1bea9f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityEmergingGrowthCompany_019c952a-b307-7f64-aef6-96b92a1bea9f" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_019c952a-b307-7496-8690-b1bd6dbd875b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityExTransitionPeriod_019c952a-b307-7496-8690-b1bd6dbd875b" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019c952a-b307-7614-a77b-ef84adaedc7a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityAddressAddressLine2_019c952a-b307-7614-a77b-ef84adaedc7a" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine3_019c952a-b307-799d-aae3-6c5b67319e75" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine3"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityAddressAddressLine3_019c952a-b307-799d-aae3-6c5b67319e75" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019c952a-b307-7e2d-8b60-e5c7f40482ad" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_EntityCentralIndexKey_019c952a-b307-7e2d-8b60-e5c7f40482ad" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019c952a-b307-77e0-991f-f7bfb057e5f6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019c952a-b307-733f-9a6c-3582ce7c6a75" xlink:to="loc_dei_AmendmentFlag_019c952a-b307-77e0-991f-f7bfb057e5f6" xlink:type="arc" order="24"/>
  </link:definitionLink>
</link:linkbase>
