<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:562e1a63-5b16-4b9c-9e62-4801a701fdcd,g:33c8bb0a-642c-4f12-a4bc-16f70ae7737a-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="wgs-20250917.xsd#DocumentandEntityInformationDocument"/>
  <link:presentationLink xlink:role="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_abab5b17-d9ff-42c3-99ab-c4c6d0f2747a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_c820226b-0732-41b4-9de0-2fdf92055235" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_abab5b17-d9ff-42c3-99ab-c4c6d0f2747a" xlink:to="loc_dei_EntitiesTable_c820226b-0732-41b4-9de0-2fdf92055235" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_d8a615e8-ca79-4a18-9d97-56964018fb99" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_c820226b-0732-41b4-9de0-2fdf92055235" xlink:to="loc_us-gaap_StatementClassOfStockAxis_d8a615e8-ca79-4a18-9d97-56964018fb99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c521aceb-a902-4d8d-b622-4035965d99e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_d8a615e8-ca79-4a18-9d97-56964018fb99" xlink:to="loc_us-gaap_ClassOfStockDomain_c521aceb-a902-4d8d-b622-4035965d99e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_0fffbb84-aa6e-4781-853b-5d74f3f689d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c521aceb-a902-4d8d-b622-4035965d99e9" xlink:to="loc_us-gaap_CommonClassAMember_0fffbb84-aa6e-4781-853b-5d74f3f689d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_8f24673a-282b-4719-9b0c-679edb87ddfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c521aceb-a902-4d8d-b622-4035965d99e9" xlink:to="loc_us-gaap_WarrantMember_8f24673a-282b-4719-9b0c-679edb87ddfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_c820226b-0732-41b4-9de0-2fdf92055235" xlink:to="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_cb8958b6-af3c-4adb-a369-81317df38050" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_DocumentType_cb8958b6-af3c-4adb-a369-81317df38050" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_abb0ba9f-a85a-4901-ae34-bc0770c6a233" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_DocumentPeriodEndDate_abb0ba9f-a85a-4901-ae34-bc0770c6a233" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_6dfbe6d5-f7fd-4d19-9988-0a4a1f11ca46" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityRegistrantName_6dfbe6d5-f7fd-4d19-9988-0a4a1f11ca46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_b6b0ae43-9c58-49cc-b8f0-5e3d25bbcf11" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityIncorporationStateCountryCode_b6b0ae43-9c58-49cc-b8f0-5e3d25bbcf11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_bf372ea1-292d-4e12-a831-8c22ae3877bc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityFileNumber_bf372ea1-292d-4e12-a831-8c22ae3877bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_68129df7-41d3-49c9-8152-1f0e533ff729" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityTaxIdentificationNumber_68129df7-41d3-49c9-8152-1f0e533ff729" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_e8d9e441-8556-4c08-8312-c570911eb1cd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityAddressAddressLine1_e8d9e441-8556-4c08-8312-c570911eb1cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_f8a4bf07-9b5a-4c41-b1e3-db1fe8c59b6c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityAddressCityOrTown_f8a4bf07-9b5a-4c41-b1e3-db1fe8c59b6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_473027b0-ccd4-4f30-8df2-a64d45266721" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityAddressStateOrProvince_473027b0-ccd4-4f30-8df2-a64d45266721" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_6f9abf57-d952-4395-835c-92f5e72de01f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityAddressPostalZipCode_6f9abf57-d952-4395-835c-92f5e72de01f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_a6aa9d5a-e634-4da8-a695-43a7b011514d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_CityAreaCode_a6aa9d5a-e634-4da8-a695-43a7b011514d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_ec75fa87-3c40-405b-ba79-e3f6bb6f2197" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_LocalPhoneNumber_ec75fa87-3c40-405b-ba79-e3f6bb6f2197" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_be3b4a2f-ca6a-4d05-a69c-63fbaf46ab68" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_WrittenCommunications_be3b4a2f-ca6a-4d05-a69c-63fbaf46ab68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_0fa5b842-1905-44ff-af4b-f79990817020" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_SolicitingMaterial_0fa5b842-1905-44ff-af4b-f79990817020" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_4aa49495-3abd-4ebf-a5cd-f006e3943302" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_PreCommencementTenderOffer_4aa49495-3abd-4ebf-a5cd-f006e3943302" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_056fc59e-50c0-4197-9926-e720ecf9bee9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_056fc59e-50c0-4197-9926-e720ecf9bee9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_81fc04ea-21aa-4351-a83c-2f15e7a69839" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_Security12bTitle_81fc04ea-21aa-4351-a83c-2f15e7a69839" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_d8b4dea0-876d-4625-b970-f7c7a10fc9a5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_TradingSymbol_d8b4dea0-876d-4625-b970-f7c7a10fc9a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_d1746265-625c-4138-8123-ee13ca2b4fa5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_SecurityExchangeName_d1746265-625c-4138-8123-ee13ca2b4fa5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_2175c6bd-7028-43f6-ac30-f2762ec72ffc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityEmergingGrowthCompany_2175c6bd-7028-43f6-ac30-f2762ec72ffc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_465a498b-16ef-441c-a243-c6bb7269829a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityExTransitionPeriod_465a498b-16ef-441c-a243-c6bb7269829a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_19335192-be24-46b2-b7db-0b29a719e12c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityAddressAddressLine2_19335192-be24-46b2-b7db-0b29a719e12c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine3_648a58bb-8994-43c0-8e9f-3f3beadf919d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine3"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityAddressAddressLine3_648a58bb-8994-43c0-8e9f-3f3beadf919d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_5e07daa4-e66f-40a1-b57e-3477da775a8a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_EntityCentralIndexKey_5e07daa4-e66f-40a1-b57e-3477da775a8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_97156c25-4e6a-4763-a6a6-f18d040b53d7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_e573ac32-2c8a-4d3d-827e-f1c2f822d36e" xlink:to="loc_dei_AmendmentFlag_97156c25-4e6a-4763-a6a6-f18d040b53d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
