<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:c335c1c2-dd8a-4903-92d4-23f37c22634d,g:2ba427a1-b758-4b09-a25b-9e29ff1e4326-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="wgs-20240108.xsd#DocumentandEntityInformationDocument"/>
  <link:definitionLink xlink:role="http://www.genedx.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_8dc70142-c3bd-43a7-9cc4-2dcfd4a24ffb" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_DocumentType_8dc70142-c3bd-43a7-9cc4-2dcfd4a24ffb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_028744e6-6478-4020-87d7-e6555851626e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_DocumentPeriodEndDate_028744e6-6478-4020-87d7-e6555851626e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_30c8f770-083c-459a-92ee-7ec7e75a1b2e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityRegistrantName_30c8f770-083c-459a-92ee-7ec7e75a1b2e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_263eec4f-8830-4171-afb9-3cd6113e0f76" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityIncorporationStateCountryCode_263eec4f-8830-4171-afb9-3cd6113e0f76" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_f50124da-bb62-4623-9a01-46cc3a9636ea" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityFileNumber_f50124da-bb62-4623-9a01-46cc3a9636ea" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_f32fdcd9-9db0-4dc4-8895-7f6f2477fce0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityTaxIdentificationNumber_f32fdcd9-9db0-4dc4-8895-7f6f2477fce0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_85615ec4-bb1f-488e-b884-739970c7a70a" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityAddressAddressLine1_85615ec4-bb1f-488e-b884-739970c7a70a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_a2bd3e5d-6d74-4af5-a0fa-f6bdb1365091" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityAddressCityOrTown_a2bd3e5d-6d74-4af5-a0fa-f6bdb1365091" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_b813bb41-ad43-4078-91ac-feb8edff65f0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityAddressStateOrProvince_b813bb41-ad43-4078-91ac-feb8edff65f0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_30656751-3e4a-478f-9730-d32f0677a332" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityAddressPostalZipCode_30656751-3e4a-478f-9730-d32f0677a332" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_75854b0f-f12d-4661-824a-d0445a4fcaa4" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_CityAreaCode_75854b0f-f12d-4661-824a-d0445a4fcaa4" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_6ce9325b-14ad-4eb1-ab49-167e41fbd9e7" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_LocalPhoneNumber_6ce9325b-14ad-4eb1-ab49-167e41fbd9e7" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_3876b3a6-5256-4cb3-9ac1-c562ed27c9f0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_WrittenCommunications_3876b3a6-5256-4cb3-9ac1-c562ed27c9f0" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_f1f056b0-4a20-4c57-a0e4-e1caed3b9f3f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_SolicitingMaterial_f1f056b0-4a20-4c57-a0e4-e1caed3b9f3f" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_b5116b87-b5c9-4971-b2bc-d88c02a0a952" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_PreCommencementTenderOffer_b5116b87-b5c9-4971-b2bc-d88c02a0a952" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_140c47f3-07f6-4353-bedf-58edac122e17" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_140c47f3-07f6-4353-bedf-58edac122e17" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_98c12770-098c-440c-948f-ca47902b0423" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_Security12bTitle_98c12770-098c-440c-948f-ca47902b0423" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_6f6aae71-99df-4fd7-b992-12d9654115da" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_TradingSymbol_6f6aae71-99df-4fd7-b992-12d9654115da" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_f56545c1-e97b-4a65-88d1-d6e64f4c525a" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_SecurityExchangeName_f56545c1-e97b-4a65-88d1-d6e64f4c525a" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_113cfeea-9cb6-46d2-b5f3-1a7b1902916f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityEmergingGrowthCompany_113cfeea-9cb6-46d2-b5f3-1a7b1902916f" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_1d655802-861a-4519-a0fb-95a8a574ae47" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityExTransitionPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityExTransitionPeriod_1d655802-861a-4519-a0fb-95a8a574ae47" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_90ea3b3f-1d56-4271-8f53-b287cb2c7502" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityAddressAddressLine2_90ea3b3f-1d56-4271-8f53-b287cb2c7502" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine3_f2e8f17d-d29f-44cd-bae2-8c204256a7f7" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine3"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityAddressAddressLine3_f2e8f17d-d29f-44cd-bae2-8c204256a7f7" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_bf24fc46-c8d1-4d2f-8ae5-a2212915c680" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntityCentralIndexKey_bf24fc46-c8d1-4d2f-8ae5-a2212915c680" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_a8dd3910-e794-4415-8c63-d2067fc57d6f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_AmendmentFlag_a8dd3910-e794-4415-8c63-d2067fc57d6f" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_5fa126a8-39de-4dd9-9e9f-53861c3d8f37" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_0809482d-7c66-46e8-9d24-de19b00bf6e1" xlink:to="loc_dei_EntitiesTable_5fa126a8-39de-4dd9-9e9f-53861c3d8f37" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_3cab8e0e-068e-4ec7-97cb-8af5bf32daa5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_5fa126a8-39de-4dd9-9e9f-53861c3d8f37" xlink:to="loc_us-gaap_StatementClassOfStockAxis_3cab8e0e-068e-4ec7-97cb-8af5bf32daa5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_3cab8e0e-068e-4ec7-97cb-8af5bf32daa5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3cab8e0e-068e-4ec7-97cb-8af5bf32daa5" xlink:to="loc_us-gaap_ClassOfStockDomain_3cab8e0e-068e-4ec7-97cb-8af5bf32daa5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c49583f1-694f-45a7-8211-909a4058f431" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3cab8e0e-068e-4ec7-97cb-8af5bf32daa5" xlink:to="loc_us-gaap_ClassOfStockDomain_c49583f1-694f-45a7-8211-909a4058f431" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_49b91f17-e81c-4ebe-aa15-d636c2147b03" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c49583f1-694f-45a7-8211-909a4058f431" xlink:to="loc_us-gaap_CommonClassAMember_49b91f17-e81c-4ebe-aa15-d636c2147b03" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_86a16d6b-17e9-4efc-b3e5-9c727507eba1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c49583f1-694f-45a7-8211-909a4058f431" xlink:to="loc_us-gaap_WarrantMember_86a16d6b-17e9-4efc-b3e5-9c727507eba1" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
