If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D






SCHEDULE 13D


 
CMLS Holdings LLC
 
Signature:By: /s/ Eli Casdin
Name/Title:Eli Casdin, Manager
Date:08/26/2025
 
C-LSH LLC
 
Signature:By: /s/ Eli Casdin
Name/Title:Eli Casdin, Managing Member
Date:08/26/2025
 
M-LSH LLC
 
Signature:By: /s/ Keith A. Meister
Name/Title:Keith A. Meister, Managing Member
Date:08/26/2025
 
Casdin Capital, LLC
 
Signature:By: /s/ Eli Casdin
Name/Title:Eli Casdin, Managing Member
Date:08/26/2025
 
Casdin Partners Master Fund, L.P.
 
Signature:By: /s/ Eli Casdin
Name/Title:Eli Casdin, Managing Member of its General Partner
Date:08/26/2025
 
Casdin Partners GP, LLC
 
Signature:By: /s/ Eli Casdin
Name/Title:Eli Casdin, Managing Member
Date:08/26/2025
 
Eli Casdin
 
Signature:By: /s/ Eli Casdin
Name/Title:Eli Casdin
Date:08/26/2025
 
Keith A. Meister
 
Signature:By: /s/ Keith A. Meister
Name/Title:Keith A. Meister
Date:08/26/2025
 
Corvex Management LP
 
Signature:By: /s/ Keith A. Meister
Name/Title:Keith Meister, Managing Partner
Date:08/26/2025
Comments accompanying signature:
* This reporting person disclaims beneficial ownership of these reported securities except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that any such person is the beneficial owner of these securities for purposes of Section 16 of the U.S. Securities Exchange Act of 1934, as amended, or for any other purpose. Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (see 18 U.S.C. 1001).

 

 

Exhibit A

 

 

AGREEMENT

 

 

The undersigned agree that this Schedule 13D amendment, dated August 26, 2025, relating to the Class A common stock, par value $0.0001 per share of GeneDx Holdings Corp. shall be filed on behalf of the undersigned.

 

 

 

 

CMLS Holdings LLC

   
  By Eli Casdin
  Eli Casdin, Manager
  August 26, 2025
 

 

C-LSH LLC

   
  By Eli Casdin
  Eli Casdin, Managing Member
  August 26, 2025
 

 

M-LSH LLC 

   
  By Keith A. Meister
  Keith A. Meister, Managing Member
  August 26, 2025
   
  Casdin Capital, LLC 
   
  By Eli Casdin
  Eli Casdin, Managing Member
  August 26, 2025
   

 

  Casdin Partners Master Fund, L.P.
   
  By Eli Casdin
  Eli Casdin, Managing Member of its General Partner
  August 26, 2025
   

 

  Casdin Partners GP, LLC 
   
  By Eli Casdin
  Eli Casdin, Managing Member
  August 26, 2025
   

 

  Eli Casdin
   
  By Eli Casdin
  Eli Casdin
  August 26, 2025
   
  Keith A. Meister 
   
  By Keith A. Meister
  Keith A. Meister
  August 26, 2025
   
  Corvex Management LP 
   
  By Keith Meister
  Keith Meister, Managing Partner
  August 26, 2025

 

 

 

 

 

Exhibit B

 

 

Schedule of Transactions in Shares

 

 

Date of Transaction

 

Title of Class

Number of Shares Acquired Number of Shares Disposed

Price Per

Share

 

August 22, 2025 Class A common stock, par value $0.0001 per share   500,000 $120.9039